Hip fractures are one of the major health problems in the elderly population [ 1 – 3 ]. Besides their immense health economical relevance [ 4 – 7 ], hip fractures usually result in substantial consequences for each individual patient. The outcome …

Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries [ 1 ]. Choroidal neovascularization, the hallmark of wet-type AMD, is responsible for the majority of cases with severe vision loss in AMD [ 2 ].

Background: Complement factor H (CFH; HF) is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma. Several polymorphisms and mutations in the complement factor H gene (CFH; HF1) have been …

DNA damage has been widely accepted to account for the initiation of a mount of ovarian carcinomas which post the most mortality in gynecologic cancers [ 1 ], primarily due to excessive exposure to carcinogens including UV, ionizing radiation …

Hip fractures are typical osteoporotic fractures in elderly patients. The increased life expectancy and increased activity levels of elderly people have led to an increased incidence of fractures at the proximal end of the femur [ 1 – 3 ]. The …

Age-related macular degeneration (AMD) is the primary cause of irreversible central visual loss in the geriatric population with deleterious global effect on the quality of life [ 1 ]. Retinal angiomatous proliferation (RAP) is a rare variant of …

Nailing techniques have changed tremendously in recent years. One significant development has been the interlocking compression nail (ICN) which provides active interfragmentary compression. Apart from its beneficial effect in the treatment of …

Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was …

Summary: We present a patient with MPS IH, homozygous for the W402X mutation. The patient was treated by bone marrow transplantation at age 14 months. The patient became pregnant at age 21 years. Because of concerns about her own health, the …

There is evidence to suggest a role for immune dysfunction in the pathogenesis of Alzheimer’s disease, and it has previously been shown that blood plasma levels of the protein complement factor H, a member of the alternative complement pathway …

In a number of recent studies, the thymidine→cytosine (T→C) substitution in exon 9 of the complement factor H (CFH) gene (rs1061170), encoding the nonsynonymous protein polymorphism Y402H, has been shown to be strongly associated with …

A retrospective cohort study using a prospectively collected database was conducted under Institutional Review Board approval. Patients were included if they were at least 16 years old and underwent adrenalectomy for any indication by surgeons in …