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  1. 01-12-2022 | Stroke | Original Research

    Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals

    High fasting plasma glucose, which constitutes diabetes mellitus, ranks only behind high blood pressure and smoking (6.53 million [5.23–8.23] deaths and 171 million [144–201] DALYs) as a cause of global burden of disease [ 1 ]. There are an …

  2. Open Access 01-12-2022 | Erratum

    Correction to: Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals

  3. 01-03-2017 | OriginalPaper

    Association of XRCC1 Arg399Gln and Arg194Trp polymorphisms with susceptibility to multiple autoimmune diseases: a meta-analysis

    The role of the X-ray repair cross-complementing gene 1(XRCC1) Arg399Gln and Arg194Trp polymorphisms has been involved in the investigations of susceptibility to multiple autoimmune diseases, but the results were inconsistent. Here, we have …

  4. 01-05-2017 | OriginalPaper

    Association of Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile with the risk of primary open angle glaucoma

    Glaucoma is a complex, heterogeneous disease characterized by a progressive loss of retinal ganglion cells (RGCs) that leads to a characteristic optic neuropathy with associated visual field loss. Primary open angle glaucoma (POAG) is the most …

  5. Open Access 01-12-2017 | OriginalPaper

    The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females

    In Kyrgyzstan, breast cancer (BC) appears to be one of the leading cancer localizations in females, remaining the second most prevalent and the third fatal type of cancer. The advanced disease is diagnosed in 40% of new cases, hampering both …

  6. 01-09-2007 | OriginalPaper

    Sick-listing as a Psychosocial Work Problem: A Survey of 3997 Swedish Physicians

    Objectives: To quantify the extent of emotionally straining sick-listing problems among three categories of physicians and find associations with workplace characteristics. Methods: A questionnaire was answered by 3997 physicians (response rate: …

  7. 01-04-2014 | OriginalPaper

    Assessment of the association between XRCC1 Arg399Gln polymorphism and glioma susceptibility

    The Arg399Gln polymorphism, located in the region of the BRCT-I interaction domain of XRCC1, has been extensively explored in its function and association with glioma risk. However, these studies generated contradictory instead of conclusive …

  8. 01-01-2011 | OriginalPaper

    A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy

    Regardless of the origin, injury to the heart can result in cardiomyocyte hypertrophy, fibrosis, and cell death. Myocarditis often progresses to dilated cardiomyopathy (DCM), a major cause of heart failure. In our study, we used a rat model of …

  9. 01-06-2015 | OriginalPaper

    The Arg399Gln polymorphism in the XRCC1 gene is associated with increased risk of hematological malignancies

    The associations between the Arg399Gln polymorphism in X-ray repair cross-complementing gene 1 (XRCC1) gene and the risk of hematological malignancies have been extensively investigated. However, the results were inconsistent. The objective of the …

  10. 01-12-2013 | OriginalPaper

    Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese

    X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair and plays an important role in the maintenance of genomic integrity. Polymorphisms in XRCC1 may alter the function and …

  11. 01-04-2007 | OriginalPaper

    A comparison of 399 open and 568 laparoscopic gastric bypasses performed during a 4-year period

    The study was conducted at Vanderbilt University Medical Center, where data of patients undergoing surgery for morbid obesity are prospectively collected and maintained in an institutional review board–approved clinical database.

  12. 01-05-2012 | OriginalPaper

    Rheumatoid arthritis risk associates with DNA repair gene XRCC1 Arg399Gln polymorphism in Turkish patients

    Rheumatoid arthritis (RA) is an autoinflammatory disease with a genetic background. The synoviocytes in RA shows cellular transformation with tumor-like features, and RA patients have genomic instability and relaxation of DNA repair mechanisms.

  13. 01-07-2011 | OriginalPaper

    Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

    It is generally accepted that increased intraocular pressure (IOP) is a major risk factor in glaucoma. However, visual-field loss sometimes occurs in glaucoma patients with well-controlled IOP. Recently, attention has been focused on the role of …

  14. 01-02-2015 | ReviewPaper

    XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis

    X-ray repair cross-complementing group 1 (XRCC1) plays a key role in DNA repair, genetic instability, and tumorigenesis. The XRCC1 R399Q polymorphism has been reported in some studies to influence the risk of colorectal cancer (CRC), though this …

  15. Open Access 01-12-2009 | OriginalPaper

    School-related mediators in social inequalities in smoking: a comparative cross-sectional study of 20,399 adolescents

    The growing recognition that social inequality in health and health behaviour is a global issue, and not only confined to affluent nations [ 1 ], has led to a demand for studies examining the mechanisms between socioeconomic status and health …

  16. 01-01-2014 | OriginalPaper

    XRCC1 Arg399Gln variation and leukemia susceptibility: evidence from 2,647 cases and 5,518 controls

    Previous reports implicate XRCC1 Arg399Gln polymorphism as a possible risk factor for several cancers. Increasing studies have been conducted on the association of XRCC1 Arg399Gln polymorphisms with susceptibility to leukemia. However, conflicting …

  17. 01-01-2014 | OriginalPaper

    XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients

    Radiotherapy is an important weapon in the treatment of breast cancer, but normal tissue injury after radiotherapy can be a threat for patients. Genetic markers conferring the ability to identify hyper-sensitive patients at risk of normal tissue …

  18. 01-01-2014 | OriginalPaper

    X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: an updated meta-analysis

    Many epidemiologic studies have investigated the association between x-ray repair cross-complementing group 1 gene (XRCC1) codon 399 polymorphism and lung cancer risk, but the results were inconsistent. We performed a meta-analysis of 46 studies …

  19. 01-01-2014 | OriginalPaper

    XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis

    Previous studies regarding the association between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and oral cancer risk were contradictory. We performed a meta-analysis to derive a more precise estimation of the …

  20. 01-07-2010 | OriginalPaper

    Haplotype analysis of XRCC1 (at codons 194 and 399) and breast cancer risk, a case–control study

    DNA in most cells is regularly damaged by endogenous and exogenous mutagens. Among DNA repair systems, the base excision repair pathway is responsible for the repair of oxidative DNA damage and single-strand breaks. The X-ray repair …

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