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  1. 14-12-2023 | Erratum

    Erratum to: Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II

  2. 20-10-2023 | OriginalPaper

    Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II

    D ementia is an ever growing disease estimated to affect a total of 78 million people worldwide by 2030, and potentially reaching 139 million by 2050 ( https://www.alzint.org/ ). Dementia’s etiopathogenesis is not completely understood and there …

  3. 30-06-2022 | Antipsychotics | OriginalPaper

    Risk of teenage pregnancy among adolescents with bipolar disorder: a cohort study of 35,398 adolescent girls

    Teenage pregnancy is a major public health concern. However, few studies have investigated the relationship between pediatric bipolar disorder and early pregnancy, and whether bipolar disorder medications reduce the risk of early pregnancy remains …

  4. 01-04-2020 | Breast Cancer | OriginalPaper

    GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models

    The selective estrogen receptor downregulator/degrader (SERD), fulvestrant was approved by FDA in 2002 as a second line endocrine therapy for breast cancer patients with progressing diseases after prior endocrine treatments such as tamoxifen or …

  5. 01-12-2020 | Diabetic Foot

    Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections

    Bone and joint infections (BJI) are a heterogeneous disease in their pathophysiology, clinical presentation, and management [ 1 ] and Staphylococcus aureus is the most common pathogen in almost all types of BJIs.

  6. Open Access 01-02-2021 | Breast Cancer | OriginalPaper

    Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures

    Genetic alterations in fibroblast growth factor receptors (FGFRs), including amplifications, single nucleotide polymorphisms (SNPs) and fusions [ 1 , 2 ], as well as FGFR ligands (fibroblast growth factors, FGFs) and downstream signaling pathways [ …3

  7. 01-11-2019 | OriginalPaper

    Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017

    The epidemiology of Staphylococcus aureus is changing and several surveillances worldwide have evidenced an increasing incidence of S. aureus bloodstream infections (BSIs). Here, we described the long-term epidemiology of the emergent clonal group …

  8. Open Access 01-12-2019 | OriginalPaper

    Unidirectional animal-to-human transmission of methicillin-resistant Staphylococcus aureus ST398 in pig farming; evidence from a surveillance study in southern Italy

    Staphylococcus aureus is a skin and mucosal commensal of humans and animals, and an important human pathogen involved in various infections, ranging from localized to life-threatening invasive diseases. Although human colonization varies with …

  9. 01-09-2021 | Gastric Cancer | OriginalPaper

    Knockdown of Bcl-2-Associated Athanogene-3 Can Enhance the Efficacy of BGJ398 via Suppressing Migration and Inducing Apoptosis in Gastric Cancer

    Gastric cancer (GC) is the third most fatal cancer, accounting for almost 1,000,000 new cases worldwide every year and causing a public health problem [ 1 , 2 ]. With recent surveillance reports, cancer diagnosis and treatment have been progressed …

  10. 01-12-2020 | Glioblastoma

    Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

    Gliomas are classified by the World Health Organization (WHO) grade criteria (I to IV) into multiple specific histologic subtypes, based on cell type of origin and molecular characteristics [ 1 ]. Grade IV Glioblastoma (GBM) is one of the most …

  11. 01-05-2018 | OriginalPaper

    CC398 Staphylococcus aureus subpopulations in Belgian patients

    Studies based on genome-wide single nucleotide polymorphisms (SNPs) supported the existence of two subpopulations in clonal complex (CC) 398 Staphylococcus aureus: an ancestral human-adapted clade (HC) and an animal-associated clade (AC). In this …

  12. Open Access 01-12-2018 | OriginalPaper

    Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

    Asthma is a heterogeneous condition characterized by chronic inflammation of the pulmonary airways [ 1 ] that currently afflicts 300 million people worldwide [ 2 ].

  13. 01-04-2019 | OriginalPaper

    A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor

    Background Preclinical studies suggest that imatinib resistance in gastrointestinal stromal tumor (GIST) can be mediated by MAP-kinase activation via fibroblast growth factor (FGF) signaling. In FGF stimulated GIST cell lines, BGJ398, a pan-FGFR …

  14. 01-08-2017 | Letter

    Clinical case of cfr-positive MRSA CC398 in Belgium

  15. Open Access 01-12-2017 | OriginalPaper

    No apparent transmission of livestock-associated methicillin-resistant Staphylococcus aureus CC398 in a survey of staff at a regional Danish hospital

    The predominant livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in Europe are strains of clonal complex 398 (CC398) [ 1 , 2 ]. In European pig production LA-MRSA essentially equals CC398 whereas in North America there is …

  16. Open Access 01-12-2017 | OriginalPaper

    Diffusion of clindamycin-resistant and erythromycin-resistant methicillin-susceptible Staphylococcus aureus (MSSA), potential ST398, in United States Veterans Health Administration Hospitals, 2003-2014

    The emergence of novel genotypes of Staphylococcus aureus (SA), either methicillin-resistant (MRSA) or methicillin-sensitive (MSSA), has implications for the availability and efficacy of empiric therapy options. Detecting and tracking such an …

  17. 01-02-2018 | OriginalPaper

    A 14-Year Study of 398 Esophageal Adenocarcinomas Diagnosed Among 156,256 EGDs Performed at Two Large Hospitals: An Inlet Patch Is Proposed as a Significant Risk Factor for Proximal Esophageal Adenocarcinoma

    While esophageal adenocarcinomas commonly arise in the distal (lower third of the) esophagus and in these cases are strongly linked to gastroesophageal reflux disease (GERD) and Barrett’s esophagus [ 1 ], esophageal adenocarcinomas rarely occur in …

  18. Open Access 01-12-2016 | OriginalPaper

    New dominant spa type t2741 in livestock-associated MRSA (CC398-MRSA-V) in Finnish fattening pigs at slaughter

    Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of nosocomial infections and was first reported in pigs in 2005 [ 1 ]. The European Centre for Disease Prevention and Control reported pronounced inter-country …

  19. Open Access 01-12-2016 | OriginalPaper

    Prevalence of colonization by methicillin-resistant Staphylococcus aureus ST398 in pigs and pig farm workers in an area of Catalonia, Spain

    Methicillin-resistant Staphylococcus aureus (MRSA) colonization can be acquired in the community (CA-MRSA) or in a hospital setting (HA-MRSA) [ 1 ]. Infections caused by CA-MRSA strains have been described, in some cases in individuals in direct or …

  20. 01-01-2012 | OriginalPaper

    NS398 induces apoptosis in non-small cell lung cancer cells

    In recent years, much focus has been given to studies on non-steroidal anti-inflammatory drugs (NSAIDs) used as anticancer drugs. Previous studies revealed that NSAIDs can induce apoptosis in various tumor cells, thereby inhibiting their growth …

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