Familial case of hereditary Pelger-Huët anomaly

Excerpt

A 23-year-old previously healthy woman was admitted to our hospital for tooth extraction. Routine peripheral blood examination showed a white blood cell count of 7.5 × 10⁹/L with normal differential counts (neutrophils 43%, eosinophils 2%, basophils 1%, monocytes 10%, and lymphocytes 44%). However, a peripheral blood smear revealed that the neutrophils all showed hyposegmentation of nuclei (27% mono-lobed and 73% bi-lobed nuclei) (Fig. 1a). Her hemoglobin level and platelet count were 13.5 g/dL and 316 × 10⁹/L, respectively. Other laboratory findings showed normal hepatic function, renal function, and C-reactive protein level. She reported no symptoms, and had not been taking any medication or supplements. We confirmed the existence of similar neutrophil-related morphological abnormalities in the peripheral blood of the patient’s biological mother, who had no medical history (Fig. 1b). On a physical examination, both the patient and her mother had no abnormal findings. The patient’s biological father had normal granulocytes. These findings were judged to be consistent with hereditary Pelger-Huët anomaly (PHA). She was discharged, and we observed no changes in complete blood count or health conditions during the 2-year follow-up period.

…