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Open Access 01-12-2012 | Research article

Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

Authors: Daniel Nilsson, Anand Kumar Andiappan, Christer Halldén, Wang De Yun, Torbjörn Säll, Chew Fook Tim, Lars-Olaf Cardell

Published in: BMC Medical Genetics | Issue 1/2012

Abstract

Background

The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.

Methods

A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.

Results

The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding risk-associated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations.

Conclusions

Haplotypes in the TLR7-TLR8 gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/13/66/prepub

Title: Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study
Authors: Daniel Nilsson
Anand Kumar Andiappan
Christer Halldén
Wang De Yun
Torbjörn Säll
Chew Fook Tim
Lars-Olaf Cardell
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2012
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-13-66

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Springer Medicine

Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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