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Intensive Care Medicine

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01-03-2020 | Tobramycin | Letter

Effect of adjunctive tobramycin inhalation versus placebo on early clinical response in the treatment of ventilator-associated pneumonia: the VAPORISE randomized-controlled trial

Authors: Jason Stokker, Mina Karami, Rogier Hoek, Diederik Gommers, Menno van der Eerden

Published in: Intensive Care Medicine | Issue 3/2020

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Kalil AC, Metersky ML, Klompas M et al (2016) Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases society of America and the American Thoracic Society. Clin Infect Dis 63(5):e61–e111CrossRef

Xu F, He LL, Che LQ, Li W, Ying SM, Chen ZH, Shen HH (2018) Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis. Crit Care 22:301CrossRef

Kollef MH, Ricard JD, Roux D, Francois B, Ischaki E, Rozgonyi Z et al (2016) A randomized trial of the amikacin fosfomycin inhalation system for the adjunctive therapy of Gram-negative ventilator-associated pneumonia: IASIS Trial. Chest 151:1239–1246. https://doi.org/10.1016/j.chest.2016.11.026 CrossRefPubMed

Bayer (BAY41-6551). Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia (INHALE-1). Clinical Trials.gov. NCT01799993 (2018).

Sweeney DA, Kalil AC (2019) Why don't we have more inhaled antibiotics to treat ventilator-associated pneumonia? Clin Microbiol Infect. https://doi.org/10.1016/j.cmi.2019.04.018 CrossRefPubMed

Title: Effect of adjunctive tobramycin inhalation versus placebo on early clinical response in the treatment of ventilator-associated pneumonia: the VAPORISE randomized-controlled trial
Authors: Jason Stokker
Mina Karami
Rogier Hoek
Diederik Gommers
Menno van der Eerden
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Tobramycin
Antibiotic
Pneumonia
Published in: Intensive Care Medicine / Issue 3/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05914-5

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Effect of adjunctive tobramycin inhalation versus placebo on early clinical response in the treatment of ventilator-associated pneumonia: the VAPORISE randomized-controlled trial

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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