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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2013

01-02-2013 | Editorial

To target or not to target APRIL in systemic lupus erythematosus: that is the question!

Authors: Jacques Morel, Michael Hahne

Published in: Arthritis Research & Therapy | Issue 1/2013

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Abstract

Among the cytokines that regulate B-cell homeostasis are the TNF-like ligands B-lymphocyte stimulator (BLyS; also B-cell activation factor) and a proliferation-inducing ligand (APRIL). BLyS and APRIL share two receptors; that is, B-cell maturation antigen and transmembrane activator and CAML interactor. Therapeutic approaches using biologics are limited for treatment of lupus patients. One previously approved drug is belimumab, which antagonizes the B-cell stimulator BLyS. Atacicept, another biologic inhibiting BLyS and APRIL, was terminated for serious adverse events - raising the question of whether APRIL should be neutralized in autoimmune diseases.
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Metadata
Title
To target or not to target APRIL in systemic lupus erythematosus: that is the question!
Authors
Jacques Morel
Michael Hahne
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2013
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4160

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Keynote webinar | Spotlight on medication adherence

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