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BMC Public Health
Published in: BMC Public Health 1/2005

Open Access 01-12-2005 | Research article

Tissue classification for the epidemiological assessment of surgical transmission of sporadic Creutzfeldt-Jakob disease. A proposal on hypothetical risk levels

Authors: Alberto Rábano, Jesús de Pedro-Cuesta, Kåre Mølbak, Åke Siden, Miguel Calero, Henning Laursen, the EUROSURGYCJD Research Group

Published in: BMC Public Health | Issue 1/2005

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Abstract

Background

Epidemiological studies on the potential role of surgery in Creutzfeldt-Jakob Disease transmission have disclosed associations with history of specific surgical interventions or reported negative results.

Methods

Within the context of a case-control study designed to address surgical risk of sporadic Creutzfeldt-Jakob Disease in Nordic European countries (EUROSURGYCJD Project), a strategy was adopted to categorise reported surgical procedures in terms of potential risk of Creutzfeldt-Jakob Disease acquisition. We took into account elements of biological plausibility, either clinically or experimentally demonstrated, such as tissue infectivity, PrP expression content or successful route of infection.

Results

We propose a classification of exposed tissues and anatomic structures, drawn up on the basis of their specific putative role as entry site for prion transmission through contact with surgical instruments that are not fully decontaminated.

Conclusions

This classification can serve as a reference, both in our study and in further epidemiological research, for categorisation of surgical procedures in terms of risk level of Creutzfeldt-Jakob Disease acquisition.
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Metadata
Title
Tissue classification for the epidemiological assessment of surgical transmission of sporadic Creutzfeldt-Jakob disease. A proposal on hypothetical risk levels
Authors
Alberto Rábano
Jesús de Pedro-Cuesta
Kåre Mølbak
Åke Siden
Miguel Calero
Henning Laursen
the EUROSURGYCJD Research Group
Publication date
01-12-2005
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2005
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-5-9

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