Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-01-2020 | Tinnitus | Otology

Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results

Authors: Alfonso Scarpa, Massimo Ralli, Pasquale Viola, Claudia Cassandro, Matteo Alicandri-Ciufelli, Maurizio Iengo, Giuseppe Chiarella, Marco de Vincentiis, Michele Cavaliere, Ettore Cassandro

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2020

Abstract

Purpose

Specially processed cereals (SPC) that increase endogenous antisecretory factor (AF) synthesis have been proposed to improve symptoms of Meniere’s disease (MD) with controversial results. The aim of this study was to evaluate the effects of SPC in patients with definite unilateral MD and compare the results to a treatment protocol with intravenous glycerol and dexamethasone.

Methods

Thirteen patients with unilateral MD were treated with SPC and 13 patients were treated with intravenous glycerol and dexamethasone for 12 months. Audio-vestibular evaluation was performed before (T0) and at the end of the treatments (T12). The number of vertigo spells were evaluated before and after therapy and the Efficacy Index (EI) was calculated. Questionnaires for hearing loss (HHIA), tinnitus (THI) and quality of life (TFL) were administered.

Results

EI decreased in the SPC group in the second semester compared to the first although not significantly (p = 0.6323). There was a significant reduction for THI score in the SPC group at T12 (p = 0.0325). No significant differences were found between the two groups at T0 (p = 0.4723), while a significant difference was found at T12 (p = 0.0041). Quality of life showed an improvement in daily activities in the SPC group compared to infusion therapy group.

Conclusion

Our study shows a reduced number of vertigo attacks and a positive effect on the discomfort generated by tinnitus and quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.

Goebel JA (2016) 2015 Equilibrium Committee Amendment to the 1995 AAO-HNS guidelines for the Definition of Meniere’s Disease. Otolaryngol Head Neck Surg 154(3):403–404. https://doi.org/10.1177/0194599816628524 CrossRefPubMed

Naganawa S, Nakashima T (2014) Visualization of endolymphatic hydrops with MR imaging in patients with Meniere's disease and related pathologies: current status of its methods and clinical significance. Jpn J Radiol 32(4):191–204. https://doi.org/10.1007/s11604-014-0290-4 CrossRefPubMed

Salt AN, Plontke SK (2010) Endolymphatic hydrops: pathophysiology and experimental models. Otolaryngol Clin North Am 43(5):971–983. https://doi.org/10.1016/j.otc.2010.05.007 CrossRefPubMedPubMedCentral

Paparella MM (1991) Methods of diagnosis and treatment of Meniere's disease. Acta Otolaryngol Suppl 485:108–119CrossRef

Ralli M, Greco A, Altissimi G, Turchetta R, Longo L, D'Aguanno V, Tombolini M, Cianfrone G, Vincentiis M (2017) Vestibular schwannoma and ipsilateral endolymphatic hydrops: an unusual association. Int Tinnitus J 21(2):128–132. https://doi.org/10.5935/0946-5448.20170024 CrossRefPubMed

Russo FY, Ralli M, De Seta D, Mancini P, Lambiase A, Artico M, de Vincentiis M, Greco A (2018) Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms. Immunol Res 66(6):675–685. https://doi.org/10.1007/s12026-018-9023-6 CrossRefPubMed

Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M (2018) Audiovestibular symptoms in systemic autoimmune diseases. J Immunol Res 2018:5798103. https://doi.org/10.1155/2018/5798103 CrossRefPubMedPubMedCentral

Hussain K, Murdin L, Schilder AG (2018) Restriction of salt, caffeine and alcohol intake for the treatment of Meniere's disease or syndrome. Cochrane Database Syst Rev 12:CD012173. 10.1002/14651858.CD012173.pub2

Crowson MG, Patki A, Tucci DL (2016) A systematic review of diuretics in the medical management of Meniere's disease. Otolaryngol Head Neck Surg 154(5):824–834. https://doi.org/10.1177/0194599816630733 CrossRefPubMed

10.

Phillips JS, Westerberg B (2011) Intratympanic steroids for Meniere's disease or syndrome. Cochrane Database Syst Rev 7:CD008514. 10.1002/14651858.CD008514.pub2

11.

Pullens B, van Benthem PP (2011) Intratympanic gentamicin for Meniere's disease or syndrome. Cochrane Database Syst Rev 3:CD008234. 10.1002/14651858.CD008234.pub2

12.

Ingvardsen CJ, Klokker M (2016) Antisecretory therapy with no improvement in functional level in Meniere's disease. Acta Otolaryngol 136(3):232–235. https://doi.org/10.3109/00016489.2015.1115551 CrossRefPubMed

13.

Leong SC, Narayan S, Lesser TH (2013) Antisecretory factor-inducing therapy improves patient-reported functional levels in Meniere's disease. Ann Otol Rhinol Laryngol 122(10):619–624CrossRef

14.

Hanner P, Rask-Andersen H, Lange S, Jennische E (2010) Antisecretory factor-inducing therapy improves the clinical outcome in patients with Meniere's disease. Acta Otolaryngol 130(2):223–227. https://doi.org/10.3109/00016480903022842 CrossRefPubMed

15.

Hanner P, Jennische E, Lange S, Lonnroth I, Wahlstrom B (2004) Increased antisecretory factor reduces vertigo in patients with Meniere's disease: a pilot study. Hear Res 190(1–2):31–36. https://doi.org/10.1016/S0378-5955(03)00368-X CrossRefPubMed

16.

Johansson E, Lange S, Lonnroth I (1997) Identification of an active site in the antisecretory factor protein. Biochim Biophys Acta 1362(2–3):177–182. https://doi.org/10.1016/s0925-4439(97)00066-5 CrossRefPubMed

17.

Johansson E, Lonnroth I, Lange S, Jonson I, Jennische E, Lonnroth C (1995) Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion. J Biol Chem 270(35):20615–20620. https://doi.org/10.1074/jbc.270.35.20615 CrossRefPubMed

18.

Bjorck S, Bosaeus I, Ek E, Jennische E, Lonnroth I, Johansson E, Lange S (2000) Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept. Gut 46(6):824–829. https://doi.org/10.1136/gut.46.6.824 CrossRefPubMedPubMedCentral

19.

Lange S, Lonnroth I, Skadhauge E (1987) Effects of the antisecretory factor in pigs. Pflugers Arch 409(3):328–332. https://doi.org/10.1007/bf00583485 CrossRefPubMed

20.

Laurenius A, Wangberg B, Lange S, Jennische E, Lundgren BK, Bosaeus I (2003) Antisecretory factor counteracts secretory diarrhoea of endocrine origin. Clin Nutr 22(6):549–552CrossRef

21.

Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease (1995) American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg 113(3):181–185. 10.1016/S0194-5998(95)70102-8

22.

Newman CW, Weinstein BE, Jacobson GP, Hug GA (1990) The Hearing Handicap Inventory for adults: psychometric adequacy and audiometric correlates. Ear Hear 11(6):430–433CrossRef

23.

Passi S, Ralli G, Capparelli E, Mammone A, Scacciatelli D, Cianfrone G (2008) The THI questionnaire: psychometric data for reliability and validity of the Italian version. Int Tinnitus J 14(1):26–33PubMed

Title: Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results
Authors: Alfonso Scarpa
Massimo Ralli
Pasquale Viola
Claudia Cassandro
Matteo Alicandri-Ciufelli
Maurizio Iengo
Giuseppe Chiarella
Marco de Vincentiis
Michele Cavaliere
Ettore Cassandro
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keywords: Tinnitus
Dexamethasone
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05682-4

At a glance: The STEP trials

Springer Medicine

Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2020

Prediction of aspiration in dysphagia using logistic regression: oral intake and self-evaluation

Longstanding diplopia after ethmoidal artery ligation for epistaxis

Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population

Omalizumab versus intranasal steroids in the post-operative management of patients with allergic fungal rhinosinusitis

Helicobacter pylori in allergic and non-allergic rhinitis does play a protective or causative role?

How a personalised transportable folding device for seating impacts dysphagia