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01-10-2004 | Original Article

TiA1 in advanced-stage classical Hodgkin’s lymphoma: no prognostic impact for positive tumour cells or number of cytotoxic cells

Authors: Sophie Camilleri-Broët, Christophe Fermé, Françoise Berger, Eric Lepage, Serge Bain, Josette Brière, Béatrice Marmey, Philippe Gaulard, Josée Audouin

Published in: Virchows Archiv | Issue 4/2004

Abstract

No reliable marker still exists for predicting those patients with Hodgkin’s lymphoma (HL) who may experience a fatal outcome. Among the factors tested in the literature, it has been suggested that the number of activated cytotoxic T cells may represent a prognostic marker in HL. In 244 samples from patients with stage-IIIB/IV HL issued from the GELA H89 trial, we have analysed TiA1 expression on Reed Sternberg (RS) cells as well as the percentage of positive reactive lymphocytes. There were 34 cases (13.7%) that showed TiA1 expression on tumour cells; whereas, in 32 cases (13.1%), TiA1-positive reactive lymphocytes represented more than 30% of the reactive lymphocytes. LMP-1 was found co-expressed with TiA1 in 10 of the 22 positive cases tested. Our study confirms that a subset of classical HL expresses cytotoxic proteins, with occasional co-expression of CD20. In stage-IIIB/IV disease, neither TiA1 expression by RS cells nor a high percentage of TiA1-positive reactive lymphocytes have a prognostic impact on outcome.

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Title: TiA1 in advanced-stage classical Hodgkin’s lymphoma: no prognostic impact for positive tumour cells or number of cytotoxic cells
Authors: Sophie Camilleri-Broët
Christophe Fermé
Françoise Berger
Eric Lepage
Serge Bain
Josette Brière
Béatrice Marmey
Philippe Gaulard
Josée Audouin
Publication date: 01-10-2004
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2004
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1057-6

At a glance: The STEP trials

Springer Medicine

TiA1 in advanced-stage classical Hodgkin’s lymphoma: no prognostic impact for positive tumour cells or number of cytotoxic cells

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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