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20-04-2023 | Thyroidectomy | Brief Report

Solitary fibrous tumor of the thyroid: report of three cases with a focus on cytological features and histological clues for malignancy

Authors: Federica Santoro, Alessandra Linari, Francesca Maletta, Renato Parente, Bruno Torchio, Esther Diana Rossi, Ilaria Messuti, Andrea Borasi, Marco Volante, Mauro Papotti

Published in: Virchows Archiv | Issue 2/2023

Abstract

Solitary fibrous tumor is a mesenchymal tumor of intermediate malignant potential characterized by a recurrent NAB2::STAT6 fusion and STAT6 nuclear expression. Primary thyroid solitary fibrous tumor is relatively uncommon, with 45 cases described in the English literature to date. Although its histologic features are characteristic, its diagnosis in the thyroid can be problematic, especially in small biopsies or cytology specimens. We herein present three new cases of thyroid solitary fibrous tumor, one of which is malignant, with new insights on the morphological spectrum and malignant potential of this tumor. We additionally provide a review of the literature with a focus on the clues and challenges of a preoperative cytological diagnosis of this tumor, which can nowadays be supported by STAT6 nuclear expression, when appropriately suspected.

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Title: Solitary fibrous tumor of the thyroid: report of three cases with a focus on cytological features and histological clues for malignancy
Authors: Federica Santoro
Alessandra Linari
Francesca Maletta
Renato Parente
Bruno Torchio
Esther Diana Rossi
Ilaria Messuti
Andrea Borasi
Marco Volante
Mauro Papotti
Publication date: 20-04-2023
Publisher: Springer Berlin Heidelberg
Keywords: Thyroidectomy
Thyroidectomy
Published in: Virchows Archiv / Issue 2/2023
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-023-03542-5

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Solitary fibrous tumor of the thyroid: report of three cases with a focus on cytological features and histological clues for malignancy

Abstract

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