Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2021

Open Access 01-12-2021 | Thyroid Disease | Case report

Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report

Authors: Rania Dannan, Sulaiman Hajji, Khaled Aljenaee

Published in: Journal of Medical Case Reports | Issue 1/2021

Login to get access

Abstract

Background

Hypothyroidism is diagnosed on the basis of laboratory tests because of the lack of specificity of the typical clinical manifestations. There is conflicting evidence on screening for hypothyroidism.

Case presentation

We report a case of an apparently healthy 19-year-old Kuwaiti woman referred to our clinic with an incidental finding of extremely high thyroid-stimulating hormone (TSH), tested at the patient’s insistence as she had a strong family history of hypothyroidism. Despite no stated complaints, the patient presented typical symptoms and signs of hypothyroidism on evaluation. Thyroid function testing was repeated by using different assays, with similar results; ultrasound imaging of the thyroid showed a typical picture of thyroiditis. Treatment with levothyroxine alleviated symptoms and the patient later became biochemically euthyroid on treatment.

Conclusion

There is controversy regarding screening asymptomatic individuals for hypothyroidism; therefore, it is important to maintain a high index of suspicion when presented with mild signs and symptoms of hypothyroidism especially with certain ethnic groups, as they may be free of the classical symptoms of disease.
Literature
1.
go back to reference Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–16.CrossRef Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–16.CrossRef
3.
go back to reference Lewandowski K. Reference ranges for TSH and thyroid hormones. Thyroid Res. 2015;8(Suppl 1):A17.CrossRef Lewandowski K. Reference ranges for TSH and thyroid hormones. Thyroid Res. 2015;8(Suppl 1):A17.CrossRef
4.
go back to reference El-Shafie KT. Clinical presentation of hypothyroidism. J Fam Community Med. 2003;10(1):55–8. El-Shafie KT. Clinical presentation of hypothyroidism. J Fam Community Med. 2003;10(1):55–8.
5.
go back to reference Al-Sultan AI, Larbi EB, Magbool G, Karima T, Bagshi M. Clinical presentation of spontaneous primary hypothyroidism in adults. Ann Saudi Med. 1995;15(2):143–7.CrossRef Al-Sultan AI, Larbi EB, Magbool G, Karima T, Bagshi M. Clinical presentation of spontaneous primary hypothyroidism in adults. Ann Saudi Med. 1995;15(2):143–7.CrossRef
6.
go back to reference Oddie TH, Boyd CM, Fisher DA, Hales IB. Incidence of signs and symptoms in thyroid disease. Med J Aust. 1972;2(18):981–6.CrossRef Oddie TH, Boyd CM, Fisher DA, Hales IB. Incidence of signs and symptoms in thyroid disease. Med J Aust. 1972;2(18):981–6.CrossRef
7.
go back to reference Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012;22(12):1200–35.CrossRef Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012;22(12):1200–35.CrossRef
8.
go back to reference LeFevre ML, Siu AL, Bibbins-Domingo K, et al. Screening for thyroid dysfunction: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2015;162(9):641–50.CrossRef LeFevre ML, Siu AL, Bibbins-Domingo K, et al. Screening for thyroid dysfunction: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2015;162(9):641–50.CrossRef
9.
go back to reference Vanderpump MPJ, Ahlquist JAO, Franklyn JA, Clayton RN. Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. Br Med J. 1996;313(7056):539–44.CrossRef Vanderpump MPJ, Ahlquist JAO, Franklyn JA, Clayton RN. Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. Br Med J. 1996;313(7056):539–44.CrossRef
Metadata
Title
Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report
Authors
Rania Dannan
Sulaiman Hajji
Khaled Aljenaee
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-021-02677-w

Other articles of this Issue 1/2021

Journal of Medical Case Reports 1/2021 Go to the issue