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European Archives of Oto-Rhino-Laryngology

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25-04-2023 | Thyroid Cancer | Head and Neck

Impact of social and economic factors on global thyroid cancer incidence and mortality

Authors: Yi-Chiung Hsu, Sheena Yi-Hsin Cheng, Ming-Nan Chien, Shih-Ping Cheng

Published in: European Archives of Oto-Rhino-Laryngology | Issue 9/2023

Abstract

Purpose

The incidence of thyroid cancer has increased substantially over the past few decades and is partially explained by overdiagnosis. Geographical variations in incidence rates were reported to be related to national development status. This study aimed to gain deeper insights into global thyroid cancer burden by incorporating additional social and economic factors to account for cross-national disparities.

Methods

We performed a multivariate analysis of age-standardized incidence and mortality data from the GLOBOCAN 2020 database for 126 countries that had more than 100 incident cases of thyroid cancer. The human development index (HDI), current health expenditure, and additional Global Health Observatory indicators were extracted from multiple sources.

Results

Age-standardized incidence was highly correlated with HDI (standardized coefficient beta = 0.523, 95% confidence interval [CI] = 0.275–0.771) among the countries studied. The prevalence of raised fasting blood glucose was associated with age-standardized mortality (beta = 0.277, 95% CI = 0.038–0.517). Generally, the mortality-to-incidence ratio was higher in males than in females. In multivariate analysis, HDI (beta = − 0.767, 95% CI = − 0.902 to − 0.633), current health expenditure (beta = 0.265, 95% CI = 0.137–0.394), and fine particulate matter (PM_2.5) concentrations (beta = 0.192, 95% CI = 0.086–0.298) were associated with mortality-to-incidence ratios.

Conclusions

National developments gauged by HDI explain the majority of the variation in incidence rates of thyroid cancer but play a smaller role in disparities in mortality rates. The association between air pollution and thyroid cancer outcomes warrants further investigation.

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Title: Impact of social and economic factors on global thyroid cancer incidence and mortality
Authors: Yi-Chiung Hsu
Sheena Yi-Hsin Cheng
Ming-Nan Chien
Shih-Ping Cheng
Publication date: 25-04-2023
Publisher: Springer Berlin Heidelberg
Keywords: Thyroid Cancer
Thyroid Cancer
Thyroid Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 9/2023
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-07992-0

2024 ASCO Annual Meeting

Springer Medicine

Impact of social and economic factors on global thyroid cancer incidence and mortality

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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