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01-04-2019 | Thrombosis | Expert's Comment

Expert’s comment concerning Grand Rounds case entitled “Retroperitoneal haematoma in a postoperative ALIF patient taking rivaroxaban for atrial fibrillation” by Deekonda P, Stokes OM, Chan D (Eur Spine J [2016]: DOI 10.1007/s00586-016-4822-8)

Author: Anthony Todd

Published in: European Spine Journal | Issue 4/2019

Excerpt

This is a clear and well-constructed case report describing retroperitoneal haemorrhage in a 72-year-old man taking the oral anticoagulant, rivaroxaban, shortly after spinal surgery and a related literature review [1]. The authors describe the patient’s presentation and bleeding management as well as summarise some key issues around NOACs and surgery. …

Deekonda P, Stokes OM, Chan D (2016) Retroperitoneal haematoma in a postoperative ALIF patient taking rivaroxaban for atrial fibrillation. Eur Spine J. https://doi.org/10.1007/s00586-016-4822-8 CrossRefPubMed

European Medicines Agency (2018) Xarelto 2.5 mg, Summary of product characteristics https://www.medicines.org.uk/emc/product/3410/smpc. Accessed 20 Nov 2018

PHARMAC, Best Practice Advocacy Centre New Zealand, New Zealand Government (2017) Guidelines for management of bleeding with dabigatran or rivaroxaban: for possible use in local management protocols. https://bpac.org.nz/2018/docs/dabigatran-rivaroxaban-bleeding-management.pdf. Accessed 20 Nov 2018

Makris M, Van Veen JJ, Tait CR, Mumford AD, Laffan M (2013) Guideline on the management of bleeding in patients on antithrombotic agents. Br J Haematol 160(1):35–46CrossRefPubMed

Clinical Excellence Commission (2017) Non-vitamin K antagonist oral anticoagulant (NOAC) Guidelines, Updated July 2017. Sydney, Australia

Sarode R, Milling TJ Jr, Refaai MA et al (2013) Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation 128:1234–1243CrossRefPubMedPubMedCentral

Levy JH, Moore KT, Neal MD, Schneider D, Marcsisin VS, Ariyawansa J, Weitz JJ (2018) Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers. Thromb Haemost 16(1):54–64CrossRef

Sørensen B, Spahn DR, Innerhofer P, Spannagl M, Rossaint R (2011) Clinical review: prothrombin complex concentrates—evaluation of safety and thrombogenicity. Crit Care 15(1):201–209CrossRefPubMedPubMedCentral

Connolly SJ, Milling TJ Jr, Eikelboom JW et al (2016) Andexanet alfa for acute major bleeding associated with factor Xa inhibitors. N Engl J Med 375(12):1131–1141. https://doi.org/10.1056/NEJMoa1607887 CrossRefPubMedPubMedCentral

10.

Radcliff KE, Ong A, Parvizi J, Post Z, Orozco F (2014) Rivaroxaban-induced epidural hematoma and cauda equina syndrome after total knee arthroplasty: a case report. Orthop Surg 2014(6):69–71. https://doi.org/10.1111/os.12085 CrossRef

11.

Zaarour M, Hassan S, Thumallapally N, Dai Q (2015) Rivaroxaban-induced nontraumatic spinal subdural hematoma: an uncommon yet life-threatening complication. Case Rep Hematol. https://doi.org/10.1155/2015/275380 CrossRefPubMedPubMedCentral

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Pollack CV, Reilly PA, Eikelboom J et al (2015) Idarucizumab for dabigatran reversal. N Engl J Med 373:511–520. https://doi.org/10.1056/NEJMoa1502000 CrossRefPubMed

13.

The EINSTEIN-PE Investigators (2012) Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 366:1287–1297. https://doi.org/10.1056/NEJMoa1113572 CrossRef

14.

United States Food and Drug Administration (2016) Xarelto medication guide https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202439s017lbl.pdf. Accessed 18 Nov 2018

15.

Hylek EM, Held C, Alexander JH et al (2014) Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: the ARISTOTLE trial (Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation): predictors, characteristics, and clinical outcomes. J Am Coll Cardiol 63(20):2148–2150. https://doi.org/10.1016/j.jacc.2014.02.549 CrossRef

16.

Saxena N, Parajuli S (2016) Spontaneous perinephric haematoma with newer oral anticoagulation in kidney transplant recipient. J Nephrol Renal Ther 2(1):1–2. https://doi.org/10.24966/NRT-7313/100002 CrossRef

17.

Douketis JD, Spyropoulos AC, Spencer FA et al (2012) Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of chest physicians evidence-based clinical practice guidelines. Chest 141(2 Suppl):e326S–e350S. https://doi.org/10.1378/chest.11-2298 CrossRefPubMedPubMedCentral

18.

Sherwood MW, Douketis JD, Patel MR et al (2014) Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation (ROCKET AF). Circulation 129(18):1850–1859CrossRefPubMedPubMedCentral

Title: Expert’s comment concerning Grand Rounds case entitled “Retroperitoneal haematoma in a postoperative ALIF patient taking rivaroxaban for atrial fibrillation” by Deekonda P, Stokes OM, Chan D (Eur Spine J [2016]: DOI 10.1007/s00586-016-4822-8)
Author: Anthony Todd
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keywords: Thrombosis
Rivaroxaban
Published in: European Spine Journal / Issue 4/2019
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-018-5843-2

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Expert’s comment concerning Grand Rounds case entitled “Retroperitoneal haematoma in a postoperative ALIF patient taking rivaroxaban for atrial fibrillation” by Deekonda P, Stokes OM, Chan D (Eur Spine J [2016]: DOI 10.1007/s00586-016-4822-8)

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