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01-01-2017 | Review Article

Thrombolysis in dementia patients with acute stroke: is it justified?

Authors: Maurizio Paciaroni, Leonardo Pantoni

Published in: Neurological Sciences | Issue 1/2017

Abstract

The administration of thrombolytic therapy in elderly patients with dementia and acute ischemic stroke may be controversial, because the reported risk of rt-PA associated intracerebral hemorrhage in these patients is higher compared with that of patients without dementia and because these patients are already disabled. Moreover, there are known risk factors for hemorrhagic transformation in patients with dementia: amyloid angiopathy, leukoaraiosis and the presence of microbleeds. In this review, we describe the impact of dementia on functional outcome following thrombolytic therapy for acute ischemic stroke and discuss some of the issues related to the use of this therapy in this specific patient’s population.

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Title: Thrombolysis in dementia patients with acute stroke: is it justified?
Authors: Maurizio Paciaroni
Leonardo Pantoni
Publication date: 01-01-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 1/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-016-2725-4

At a glance: The STEP trials

Springer Medicine

Thrombolysis in dementia patients with acute stroke: is it justified?

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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