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01-07-2012 | Case Report

Thick corpus callosum: a clue to the diagnosis of fetal septopreoptic holoprosencephaly?

Authors: Mériam Koob, Anne-sophie Weingertner, Bernard Gasser, Estanislao Oubel, Jean-Louis Dietemann

Published in: Pediatric Radiology | Issue 7/2012

Abstract

We describe fetal septopreoptic holoprosencephaly (HPE) associated with a thick corpus callosum (CC) diagnosed with MRI in a fetus at 31 weeks’ gestation. Our report supports a recently published study connecting a thick fetal CC to other brain abnormalities. On diffusion tensor imaging (DTI), the body of the CC contained an abnormal longitudinal bundle, presumed to be a congenital heterotopic cingulum. Prenatal and postmortem brain MRI with DTI, CT, and pathological analyses are described and illustrated.

Rypens F, Sonigo P, Aubry MC et al (1996) Prenatal MR diagnosis of a thick corpus callosum. AJNR 17:1918–1920PubMed

Lerman-Sagie T, Ben-Sira L, Achiron R et al (2009) Thick fetal corpus callosum: an ominous sign? Ultrasound Obstet Gynecol 34:55–61PubMedCrossRef

Hahn JS, Barnes PD, Clegg NJ et al (2010) Septopreoptic holoprosencephaly: a mild subtype associated with midline craniofacial anomalies. AJNR 31:1596–1601PubMedCrossRef

Vachha B, Adams RC, Rollins NK (2006) Limbic tract anomalies in pediatric myelomeningocele and Chiari II malformation: anatomic correlations with memory and learning—initial investigation. Radiology 240:194–202PubMedCrossRef

Hahn JS, Barnes PD (2010) Neuroimaging advances in holoprosencephaly: refining the spectrum of the midline malformation. Am J Med Genet C Semin Med Genet 154:120–132

Marcorelles P, Laquerriere A (2010) Neuropathology of holoprosencephalies. Am J Med Genet C Semin Med Genet 154:109–119

Rollins N (2005) Semilobar holoprosencephaly seen with diffusion tensor imaging and fiber tracking. AJNR 26:2148–2152PubMed

Kasprian G, Brugger PC, Weber M et al (2008) In utero tractography of fetal white matter development. NeuroImage 43(2):213–224PubMedCrossRef

Title: Thick corpus callosum: a clue to the diagnosis of fetal septopreoptic holoprosencephaly?
Authors: Mériam Koob
Anne-sophie Weingertner
Bernard Gasser
Estanislao Oubel
Jean-Louis Dietemann
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-011-2260-7

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Thick corpus callosum: a clue to the diagnosis of fetal septopreoptic holoprosencephaly?

Abstract

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Abstract

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Hermes

Floyd H. Gilles and Marvin D. Nelson: The developing human brain: growth and adversities (1st edn)