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01-04-2019 | Review Article

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms

Authors: Yuqing Yan, Jiezhong Yu, Ye Gao, Gajendra Kumar, Minfang Guo, Yijin Zhao, Qingli Fang, Huiyu Zhang, Jingwen Yu, Yuqiang Jiang, Han-Ting Zhang, Cun-Gen Ma

Published in: Metabolic Brain Disease | Issue 2/2019

Abstract

Multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disease (AD), and other neurodegenerative diseases of central nervous system (CNS) disorders are serious human health problems. Rho-kinase (ROCK) is emerging as a potentially important therapeutic target relevant to inflammatory neurodegeneration diseases. This is supported by studies showing the beneficial effects of fasudil, a ROCK inhibitor, in inflammatory neurodegeneration diseases. MS is an autoimmune disease resulting from inflammation and demyelination in the white matter of the CNS. It has been postulated that activation of Rho/ROCK causes neuropathological changes accompanied with related clinical symptoms, which are improved by treatment with ROCK inhibitors. Therefore, inhibition of abnormal activation of the Rho/ROCK signaling pathway appears to be a new mechanism for treating CNS diseases. In this review, we extensively discussed the role of ROCK inhibitors, summarized the efficacy of fasudil in the MS conventional animal model of experimental autoimmune encephalomyelitis (EAE), both in vivo and in vitro, and highlighted the mechanism involved. Overall, the findings collected in this review support the role of the ROCK signaling pathway in neurodegenerative diseases. Hence, ROCK inhibitors such as fasudil can be novel, and efficacious treatment for inflammatory neurodegenerative diseases.

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Title: Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms
Authors: Yuqing Yan
Jiezhong Yu
Ye Gao
Gajendra Kumar
Minfang Guo
Yijin Zhao
Qingli Fang
Huiyu Zhang
Jingwen Yu
Yuqiang Jiang
Han-Ting Zhang
Cun-Gen Ma
Publication date: 01-04-2019
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 2/2019
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0355-7

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Springer Medicine

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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