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Critical Care
Published in: Critical Care 2/2011

01-04-2011 | Commentary

Therapeutic hypothermia post out-of-hospital cardiac arrest - more questions than answers?

Author: Richard Lyon

Published in: Critical Care | Issue 2/2011

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Abstract

Nearly a decade since the introduction of therapeutic hypothermia to the ICU for cooling out-of-hospital cardiac arrest patients, key questions remain unanswered: when should cooling be initiated, how rapidly should the patient be cooled and using which device? The Time to Target Temperature study group provides important baseline data on the striking direct relationship between body temperature and survival from out-of-hospital cardiac arrest.
Literature
1.
Haugk M, Testori C, Sterz F, Uranitsch M, Holzer M, Behringer W, Herkner H, Time To Target Temperature Study Group: Relationship between time to target temperature and outcome in patients treated with therapeutic hypothermia after cardiac arrest. Crit Care 2011, 15: R101. 10.1186/cc10116PubMedCentralCrossRefPubMed
2.
Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346: 549-556. 10.1056/NEJMoa012689CrossRef
3.
Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346: 557-563. 10.1056/NEJMoa003289CrossRefPubMed
4.
Castrén M, Nordberg P, Svensson L, Taccone F, Vincent JL, Desruelles D, Eichwede F, Mols P, Schwab T, Vergnion M, Storm C, Pesenti A, Pachl J, Guérisse F, Elste T, Roessler M, Fritz H, Durnez P, Busch HJ, Inderbitzen B, Barbut D: Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation 2010, 122: 729-736. 10.1161/CIRCULATIONAHA.109.931691CrossRefPubMed
5.
Lyon RM, Richardson SE, Hay AW, Andrews PJ, Robertson CE, Clegg GR: Esophageal temperature after out-of-hospital cardiac arrest: an observational study. Resuscitation 2010, 81: 867-871. 10.1016/j.resuscitation.2010.03.017CrossRefPubMed
Metadata
Title
Therapeutic hypothermia post out-of-hospital cardiac arrest - more questions than answers?
Author
Richard Lyon
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10123

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