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Child's Nervous System

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01-02-2017 | Original Paper

Therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy is associated with short-term reduction of seizures after discharge from the neonatal intensive care unit

Authors: Suman Ghosh, Lily Tran, Jonathan J Shuster, Mary L Zupanc

Published in: Child's Nervous System | Issue 2/2017

Abstract

Introduction

Therapeutic hypothermia for the treatment of moderate to severe neonatal hypoxic ischemic encephalopathy has been shown to reduce death and disability, but the effects on seizures after discharge from the Neonatal ICU are not known.

Methods

A retrospective cohort study was conducted involving 56 neonates admitted to the Neonatal ICU at Children’s Hospital of Orange County, CA from January 1, 2007 to September 1, 2013 with hypoxic ischemic encephalopathy who met criteria for selective brain cooling. Fifteen patients received supportive care. Forty-one patients received cooling, of whom 25 were included for analysis. Sixteen patients from the hypothermia group and 12 from the no hypothermia group developed clinical seizures while inpatient. Up to 6 months, four patients (16%) had continued seizures in the therapeutic hypothermia group compared to eight (53%) patients who did not receive hypothermia.

Discussion

Our study shows an association between therapeutic hypothermia and reduced seizures after discharge from the neonatal intensive care unit. The short duration of follow-up, 6 months, is a limitation of this study. Another limitation is its observational nature, where reasons for treatment selection and exclusions are unmeasurable confounding factors. Further studies are needed to determine long-term effects.

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Title: Therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy is associated with short-term reduction of seizures after discharge from the neonatal intensive care unit
Authors: Suman Ghosh
Lily Tran
Jonathan J Shuster
Mary L Zupanc
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 2/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-016-3321-x

At a glance: The STEP trials

Springer Medicine

Therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy is associated with short-term reduction of seizures after discharge from the neonatal intensive care unit

Abstract

Introduction

Methods

Discussion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Discussion

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