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BMC Ophthalmology

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Open Access 01-12-2019 | Research article

Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens

Authors: Bo Li, Yunchun Zou, Liwen Li, Hongwei Deng, Wei Mi, Xing Wang, Ximin Yin

Published in: BMC Ophthalmology | Issue 1/2019

Abstract

Background

Exploring the role of vasoactive intestinal peptide (VIP) in the lateral geniculate body (LGBd) in visual development and studying the therapeutic effect of VIP on amblyopic kittens.

Methods

Three-week-old domestic cats were divided into a control group (n = 10) and a monocular deprivation group (n = 20), with an eye mask covering the right eye of those in the deprived group. After pattern visual evoked potential (PVEP) recording confirmed the formation of monocular amblyopia, the left LGBd was isolated from 5 kittens in each group. The remaining control kittens continued to be raised, and the remaining deprivation group was divided into a VIP intervention group (n = 5), Sefsol (caprylic acid monoglyceride, VIP solution) intervention group (n = 5) and amblyopia non-intervention group (n = 5) after removal of the eye mask. Three weeks later, PVEPs, VIP immunohistochemistry and VIP mRNA expression in the left LGBd were compared across groups.

Results

At 6 weeks of age, there were significant differences in P100 wave latency and amplitude and VIP immunohistochemistry and in situ hybridization between the control group and the deprivation group (P < 0.05). After 3 weeks of the corresponding interventions, the latency and amplitude in the VIP intervention group were better than that in the Sefsol intervention group and amblyopia non-intervention group (P < 0.05). Furthermore, VIP treatment increased the number of immunohistochemical VIP-positive cells (P < 0.05) and the average optical density of positive cells (P > 0.05), as well as the number (P < 0.05) and average optical density of VIP mRNA-positive cells (P < 0.05).

Conclusions

VIP plays an important role in visual development. Nasal administration of VIP can improve the function of neurons in the LGBd of kittens and has a certain therapeutic effect on amblyopia.

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Title: Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens
Authors: Bo Li
Yunchun Zou
Liwen Li
Hongwei Deng
Wei Mi
Xing Wang
Ximin Yin
Publication date: 01-12-2019
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2019
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-019-1203-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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