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01-06-2018 | Original Article

Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters

Authors: Ana Márcia Viana Wanzeler, Sergio Melo Alves Júnior, Jessica Teixeira Gomes, Eduardo Henrique Herbster Gouveia, Higor Yuri Bezerra Henriques, Rosa Helena Chaves, Bruno Moreira Soares, Hugo Leonardo Crisóstomo Salgado, Alberdan Silva Santos, Fabrício Mesquita Tuji

Published in: Clinical Oral Investigations | Issue 5/2018

Abstract

Objectives

The aim of this study was to investigate the healing activity of andiroba (Carapa guianensis Aubl.) against oral mucositis (OM) induced by 5-fluorouracil in golden Syrian hamsters.

Materials and methods

A total of 122 animals were randomized and divided into six groups: andiroba oil 100%, andiroba oil 10%, andiroba oil 10% refined, no treatment group, all n = 28; and negative control (NC) and cyclophosphamide (CPA) groups, both n = 5. OM was induced by intraperitoneal administration of 60 mg/kg 5-FU on days 0, 5 and 10 followed by mechanical trauma on the oral mucosa on days 1 and 2. From day 1 to day 15, the animals of the andiroba group were treated three times a day. On days 4, 8, 12 and 15, the mucosa was photographed and removed for clinical and histopathological analysis. The bone marrow of the femur was removed and the micronucleus test was performed to evaluate the cytotoxicity and genotoxicity. The data were subjected to analysis of variance, followed by the Tukey and Bonferroni test.

Results

Treatment with 100% andiroba oil reduced the degree of OM compared to that reported in the other groups (p < 0.05). Andiroba oil at both concentrations was not cytotoxic, but treatment with 100% andiroba oil showed a genotoxic potential (p < 0.001).

Conclusions

Frequent administration of andiroba oil accelerated the healing process in an experimental model of 5-fluorouracil-induced OM. However, the genotoxicity of andiroba in other cell systems and under other conditions are being tested.

Clinical relevance

The use of andiroba in topical form may be associated with reduced intensity of OM. Seek therapeutic alternatives to minimize the pain and suffering that these side effects cause cancer patients is an important scientific step.

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Title: Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters
Authors: Ana Márcia Viana Wanzeler
Sergio Melo Alves Júnior
Jessica Teixeira Gomes
Eduardo Henrique Herbster Gouveia
Higor Yuri Bezerra Henriques
Rosa Helena Chaves
Bruno Moreira Soares
Hugo Leonardo Crisóstomo Salgado
Alberdan Silva Santos
Fabrício Mesquita Tuji
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 5/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2300-2

At a glance: The STEP trials

Springer Medicine

Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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