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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2015

01-12-2015 | Gastrointestinal Oncology

Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer

Authors: Hironori Tsujimoto, MD, PhD, Yuji Morimoto, MD, PhD, Risa Takahata, MD, PhD, Shinsuke Nomura, MD, Kazumichi Yoshida, MD, PhD, Shuichi Hiraki, MD, PhD, Hiroyuki Horiguchi, MD, Hiromi Miyazaki, PhD, Satoshi Ono, MD, PhD, Daizo Saito, MD, PhD, Isao Hara, PhD, Eiichi Ozeki, PhD, Junji Yamamoto, MD, PhD, Kazuo Hase, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2015

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Abstract

Background

Preoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.

Methods

In the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.

Results

In vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.

Conclusions

ICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer.
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Metadata
Title
Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer
Authors
Hironori Tsujimoto, MD, PhD
Yuji Morimoto, MD, PhD
Risa Takahata, MD, PhD
Shinsuke Nomura, MD
Kazumichi Yoshida, MD, PhD
Shuichi Hiraki, MD, PhD
Hiroyuki Horiguchi, MD
Hiromi Miyazaki, PhD
Satoshi Ono, MD, PhD
Daizo Saito, MD, PhD
Isao Hara, PhD
Eiichi Ozeki, PhD
Junji Yamamoto, MD, PhD
Kazuo Hase, MD, PhD
Publication date
01-12-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-4594-0

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