Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Urolithiasis
Published in: Urolithiasis 3/2015

01-06-2015 | Original Paper

The visceral fat compartment is independently associated with changes in urine constituent excretion in a stone forming population

Authors: Ethan B. Fram, Ilir Agalliu, Joseph DiVito, David M. Hoenig, Joshua M. Stern

Published in: Urolithiasis | Issue 3/2015

Login to get access

Abstract

The objective of this study was to identify the independent effect of visceral fat on urine constituent excretion in a stone forming population. Using a database of 382 kidney stone patients with available visceral fat quantification, we created multiple linear regression models predicting changes in urinary solutes based on visceral fat area and body mass-index, divided by gender. Chi-square tests were used to compare stone composition by body mass-index and visceral fat area. Visceral fat predicts increases in urinary creatinine, sodium, and volume in men, but only urinary phosphate in women. In women, total body mass-index does not appear to modify this effect, but in men it is more pronounced in overweight patients for creatinine and volume only. Elevated visceral fat is associated with increased probability of uric acid stone composition. Different fat compartments likely effect urine composition in different ways. This effect appears to be different in men and women. Understanding and quantifying the effects of different fat compartments is probably important to understanding the metabolism of urolithiasis.
Literature
1.
Komlos J, Brabec M (2011) The trend of BMI values of US adults by deciles, birth cohorts 1882–1986 stratified by gender and ethnicity. Econ Hum Biol 9(3):234–250CrossRefPubMed
2.
May AL et al (2013) Obesity—United States, 1999–2010. MMWR Surveill Summ 62(Suppl 3):120–128PubMed
3.
4.
5.
Al-Hayek S et al (2013) The impact of obesity on urine composition and nephrolithiasis management. J Endourol 27(3):379–383CrossRefPubMed
6.
Taylor EN, Curhan GC (2006) Body size and 24-hour urine composition. Am J Kidney Dis 48(6):905–915CrossRefPubMed
7.
Shiina Y, Homma Y (2013) Relationships between the visceral fat area on CT and coronary risk factor markers. Intern Med 52(16):1775–1780CrossRefPubMed
8.
Kim TH et al (2012) The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. Diabetol Metab Syndr 4(1):3CrossRefPubMedCentralPubMed
9.
10.
Lupattelli G et al (2013) Insulin resistance and not BMI is the major determinant of early vascular impairment in patients with morbid obesity. J Atheroscler Thromb 20(12):924–933CrossRefPubMed
11.
12.
Zhou T et al (2013) Effects of visceral fat area and other metabolic parameters on stone composition in patients undergoing percutaneous nephrolithotomy. J Urol 190(4):1416–1420CrossRefPubMed
13.
Takahashi S et al (1997) Close correlation between visceral fat accumulation and uric acid metabolism in healthy men. Metabolism 46(10):1162–1165CrossRefPubMed
14.
Despres JP et al (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28(6):1039–1049CrossRefPubMed
15.
Maurovich-Horvat P et al (2007) Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond) 31(3):500–506CrossRef
16.
17.
Rosito GA et al (2008) Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 117(5):605–613CrossRefPubMed
18.
Eisner BH, Eisenberg ML, Stoller ML (2010) Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis. Urology 75(6):1289–1293CrossRefPubMed
19.
Fox CS et al (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116(1):39–48CrossRefPubMed
20.
Mehta TH, Goldfarb DS (2012) Uric acid stones and hyperuricosuria. Adv Chronic Kidney Dis 19(6):413–418CrossRefPubMed
21.
Flegal KM et al (2012) Prevalence of obesity and trends in the distribution of body mass index among us adults, 1999–2010. JAMA 307(5):491–497CrossRefPubMed
Metadata
Title
The visceral fat compartment is independently associated with changes in urine constituent excretion in a stone forming population
Authors
Ethan B. Fram
Ilir Agalliu
Joseph DiVito
David M. Hoenig
Joshua M. Stern
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
Urolithiasis / Issue 3/2015
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-015-0770-8

Other articles of this Issue 3/2015

Urolithiasis 3/2015 Go to the issue

Original Paper

Initial experiences with laparoscopy and flexible ureteroscopy combination pyeloplasty in management of ectopic pelvic kidney with stone and ureter–pelvic junction obstruction

Original Paper

Predictive parameters for medical expulsive therapy in ureteral stones: a critical evaluation

Original Paper

Percutaneous nephrolithotomy in solitary kidneys: experience with 412 cases from Southern Iran

Original Paper

Percutaneous nephrolithotomy for infection stones: what is the risk for postoperative sepsis? A retrospective cohort study

Original Paper

Supine or prone position for mini-PNL procedure: does it matter

Original Paper

Urinary stone composition in Oman: with high incidence of cystinuria