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Published in: Journal of Clinical Monitoring and Computing 6/2015

01-12-2015 | Original Research

The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children

Authors: Jamal Garah, Orly Eshach Adiv, Irit Rosen, Ron Shaoul

Published in: Journal of Clinical Monitoring and Computing | Issue 6/2015

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Abstract

The Integrated Pulmonary Index (IPI) is an algorithm included in commercially available monitors that constitutes a representation of 4 parameters: EtCO2, RR, SpO2 and PR. The IPI index has been validated for adults and children older than 1 year of age. In this study we aimed to study the value of IPI monitoring during pediatric endoscopic procedures. Our data consisted of 124 measurements of 109 patients undergoing different procedures (upper endoscopy 84 patients, colonoscopy 6 patients, both 9 patients). The data was divided into 3 groups based on the drug type used: propofol only, 5 patients (group 1); propofol & midazolam, 89 patients (group 2); propofol, midazolam and Fentanyl, 15 patients (group 3). Patients in group 2 and 3 had significantly higher IPI levels than group 1. Significantly lower IPI values were found between ages 4–6 compared to 7–12 years old. High midazolam dose was associated with lower IPI levels during the procedure. No significant differences were found for propofol doses. Patients who had an anesthetist present had lower IPI levels during the procedure compared to those who did not. No differences were noted between the different procedures. IPI alerted all apnea episodes (58 events, IPI = 1) and hypoxia (26 events, IPI ≤ 3) episodes, whereas pulse oximetry captured only the hypoxia episodes (IPI sensitivity = 1, specificity 0.98, positive predictive value 0.95). Younger patient age, use of propofol alone, higher midazolam doses and presence of anesthetist are all associated with lower IPI levels.
Literature
1.
go back to reference Cohen LB, Delegge MH, Aisenberg J, Brill JV, Inadomi JM, Kochman ML, Piorkowski JD Jr. AGA Institute review of endoscopic sedation. Gastroenterology. 2007;133(2):675–701.CrossRefPubMed Cohen LB, Delegge MH, Aisenberg J, Brill JV, Inadomi JM, Kochman ML, Piorkowski JD Jr. AGA Institute review of endoscopic sedation. Gastroenterology. 2007;133(2):675–701.CrossRefPubMed
2.
go back to reference Radaelli F, Terruzzi V, Minoli G. Extended/advanced monitoring techniques in gastrointestinal endoscopy. Gastrointest Endosc Clin N Am. 2004;14(2):335–52.CrossRefPubMed Radaelli F, Terruzzi V, Minoli G. Extended/advanced monitoring techniques in gastrointestinal endoscopy. Gastrointest Endosc Clin N Am. 2004;14(2):335–52.CrossRefPubMed
3.
go back to reference Waring JP, Baron TH, Hirota WK, Goldstein JL, Jacobson BC, Leighton JA, Mallery JS, Faigel DO. Guidelines for conscious sedation and monitoring during gastrointestinal endoscopy. Gastrointest Endosc. 2003;58(3):317–22.CrossRefPubMed Waring JP, Baron TH, Hirota WK, Goldstein JL, Jacobson BC, Leighton JA, Mallery JS, Faigel DO. Guidelines for conscious sedation and monitoring during gastrointestinal endoscopy. Gastrointest Endosc. 2003;58(3):317–22.CrossRefPubMed
4.
go back to reference Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics. 2006;118(6):2587–602.CrossRefPubMed Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics. 2006;118(6):2587–602.CrossRefPubMed
5.
go back to reference Lichtenstein DR, Jagannath S, Baron TH, Anderson MA, Banerjee S, Dominitz JA, Fanelli RD, Gan SI, Harrison ME, Ikenberry SO, Shen B, Stewart L, Khan K, Vargo JJ. Sedation and anesthesia in GI endoscopy. Gastrointest Endosc. 2008;68(5):815–26.CrossRefPubMed Lichtenstein DR, Jagannath S, Baron TH, Anderson MA, Banerjee S, Dominitz JA, Fanelli RD, Gan SI, Harrison ME, Ikenberry SO, Shen B, Stewart L, Khan K, Vargo JJ. Sedation and anesthesia in GI endoscopy. Gastrointest Endosc. 2008;68(5):815–26.CrossRefPubMed
6.
go back to reference Dar AQ, Shah ZA. Anesthesia and sedation in pediatric gastrointestinal endoscopic procedures: a review. World J Gastrointest Endosc. 2010;2(7):257–62.PubMedCentralCrossRefPubMed Dar AQ, Shah ZA. Anesthesia and sedation in pediatric gastrointestinal endoscopic procedures: a review. World J Gastrointest Endosc. 2010;2(7):257–62.PubMedCentralCrossRefPubMed
7.
go back to reference Koniaris LG, Wilson S, Drugas G, Simmons W. Capnographic monitoring of ventilatory status during moderate (conscious) sedation. Surg Endosc. 2003;17(8):1261–5.CrossRefPubMed Koniaris LG, Wilson S, Drugas G, Simmons W. Capnographic monitoring of ventilatory status during moderate (conscious) sedation. Surg Endosc. 2003;17(8):1261–5.CrossRefPubMed
8.
go back to reference Vargo JJ, Cohen LB, Rex DK, Kwo PY. Position statement: nonanesthesiologist administration of propofol for GI endoscopy. Gastroenterology. 2009;137(6):2161–7.CrossRefPubMed Vargo JJ, Cohen LB, Rex DK, Kwo PY. Position statement: nonanesthesiologist administration of propofol for GI endoscopy. Gastroenterology. 2009;137(6):2161–7.CrossRefPubMed
9.
go back to reference American Academy of Pediatrics Committee on Drugs. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics. 1992;89(6 Pt 1):1110–5. American Academy of Pediatrics Committee on Drugs. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics. 1992;89(6 Pt 1):1110–5.
10.
go back to reference Beitz A, Riphaus A, Meining A, Kronshage T, Geist C, Wagenpfeil S, Weber A, Jung A, Bajbouj M, Pox C, Schneider G, Schmid RM, Wehrmann T, von DS. Capnographic monitoring reduces the incidence of arterial oxygen desaturation and hypoxemia during propofol sedation for colonoscopy: a randomized, controlled study (ColoCap Study). Am J Gastroenterol. 2012;107(8):1205–12.CrossRefPubMed Beitz A, Riphaus A, Meining A, Kronshage T, Geist C, Wagenpfeil S, Weber A, Jung A, Bajbouj M, Pox C, Schneider G, Schmid RM, Wehrmann T, von DS. Capnographic monitoring reduces the incidence of arterial oxygen desaturation and hypoxemia during propofol sedation for colonoscopy: a randomized, controlled study (ColoCap Study). Am J Gastroenterol. 2012;107(8):1205–12.CrossRefPubMed
11.
go back to reference Berkenbosch JW, Lam J, Burd RS, Tobias JD. Noninvasive monitoring of carbon dioxide during mechanical ventilation in older children: end-tidal versus transcutaneous techniques. Anesth Analg. 2001;92(6):1427–31.CrossRefPubMed Berkenbosch JW, Lam J, Burd RS, Tobias JD. Noninvasive monitoring of carbon dioxide during mechanical ventilation in older children: end-tidal versus transcutaneous techniques. Anesth Analg. 2001;92(6):1427–31.CrossRefPubMed
12.
go back to reference Berkenstadt H, Ben-Menachem E, Herman A, Dach R. An evaluation of the Integrated Pulmonary Index (IPI) for the detection of respiratory events in sedated patients undergoing colonoscopy. J Clin Monit Comput. 2012;26(3):177–81.CrossRefPubMed Berkenstadt H, Ben-Menachem E, Herman A, Dach R. An evaluation of the Integrated Pulmonary Index (IPI) for the detection of respiratory events in sedated patients undergoing colonoscopy. J Clin Monit Comput. 2012;26(3):177–81.CrossRefPubMed
13.
go back to reference Bhende MS. End-tidal carbon dioxide monitoring in pediatrics: concepts and technology. J Postgrad Med. 2001;47(2):153–6.PubMed Bhende MS. End-tidal carbon dioxide monitoring in pediatrics: concepts and technology. J Postgrad Med. 2001;47(2):153–6.PubMed
14.
go back to reference Cacho G, Perez-Calle JL, Barbado A, Lledo JL, Ojea R, Fernandez-Rodriguez CM. Capnography is superior to pulse oximetry for the detection of respiratory depression during colonoscopy. Rev Esp Enferm Dig. 2010;102(2):86–9.CrossRefPubMed Cacho G, Perez-Calle JL, Barbado A, Lledo JL, Ojea R, Fernandez-Rodriguez CM. Capnography is superior to pulse oximetry for the detection of respiratory depression during colonoscopy. Rev Esp Enferm Dig. 2010;102(2):86–9.CrossRefPubMed
15.
go back to reference Hart LS, Berns SD, Houck CS, Boenning DA. The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. Pediatr Emerg Care. 1997;13(3):189–93.CrossRefPubMed Hart LS, Berns SD, Houck CS, Boenning DA. The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. Pediatr Emerg Care. 1997;13(3):189–93.CrossRefPubMed
16.
go back to reference Heuss LT, Chhajed PN, Schnieper P, Hirt T, Beglinger C. Combined pulse oximetry/cutaneous carbon dioxide tension monitoring during colonoscopies: pilot study with a smart ear clip. Digestion. 2004;70(3):152–8.CrossRefPubMed Heuss LT, Chhajed PN, Schnieper P, Hirt T, Beglinger C. Combined pulse oximetry/cutaneous carbon dioxide tension monitoring during colonoscopies: pilot study with a smart ear clip. Digestion. 2004;70(3):152–8.CrossRefPubMed
17.
go back to reference Kunkov S, Pinedo V, Silver EJ, Crain EF. Predicting the need for hospitalization in acute childhood asthma using end-tidal capnography. Pediatr Emerg Care. 2005;21(9):574–7.CrossRefPubMed Kunkov S, Pinedo V, Silver EJ, Crain EF. Predicting the need for hospitalization in acute childhood asthma using end-tidal capnography. Pediatr Emerg Care. 2005;21(9):574–7.CrossRefPubMed
18.
go back to reference Lightdale JR, Goldmann DA, Feldman HA, Newburg AR, DiNardo JA, Fox VL. Microstream capnography improves patient monitoring during moderate sedation: a randomized, controlled trial. Pediatrics. 2006;117(6):e1170–8.CrossRefPubMed Lightdale JR, Goldmann DA, Feldman HA, Newburg AR, DiNardo JA, Fox VL. Microstream capnography improves patient monitoring during moderate sedation: a randomized, controlled trial. Pediatrics. 2006;117(6):e1170–8.CrossRefPubMed
19.
go back to reference McQuillen KK, Steele DW. Capnography during sedation/analgesia in the pediatric emergency department. Pediatr Emerg Care. 2000;16(6):401–4.CrossRefPubMed McQuillen KK, Steele DW. Capnography during sedation/analgesia in the pediatric emergency department. Pediatr Emerg Care. 2000;16(6):401–4.CrossRefPubMed
20.
go back to reference Nagler J, Wright RO, Krauss B. End-tidal carbon dioxide as a measure of acidosis among children with gastroenteritis. Pediatrics. 2006;118(1):260–7.CrossRefPubMed Nagler J, Wright RO, Krauss B. End-tidal carbon dioxide as a measure of acidosis among children with gastroenteritis. Pediatrics. 2006;118(1):260–7.CrossRefPubMed
21.
go back to reference Nelson DB, Freeman ML, Silvis SE, Cass OW, Yakshe PN, Vennes J, Stahnke LL, Herman M, Hodges J. A randomized, controlled trial of transcutaneous carbon dioxide monitoring during ERCP. Gastrointest Endosc. 2000;51(3):288–95.CrossRefPubMed Nelson DB, Freeman ML, Silvis SE, Cass OW, Yakshe PN, Vennes J, Stahnke LL, Herman M, Hodges J. A randomized, controlled trial of transcutaneous carbon dioxide monitoring during ERCP. Gastrointest Endosc. 2000;51(3):288–95.CrossRefPubMed
22.
go back to reference Sullivan KJ, Kissoon N, Goodwin SR. End-tidal carbon dioxide monitoring in pediatric emergencies. Pediatr Emerg Care. 2005;21(5):327–32.CrossRefPubMed Sullivan KJ, Kissoon N, Goodwin SR. End-tidal carbon dioxide monitoring in pediatric emergencies. Pediatr Emerg Care. 2005;21(5):327–32.CrossRefPubMed
23.
go back to reference Thakkar K, El-Serag HB, Mattek N, Gilger MA. Complications of pediatric EGD: a 4-year experience in PEDS-CORI. Gastrointest Endosc. 2007;65(2):213–21.CrossRefPubMed Thakkar K, El-Serag HB, Mattek N, Gilger MA. Complications of pediatric EGD: a 4-year experience in PEDS-CORI. Gastrointest Endosc. 2007;65(2):213–21.CrossRefPubMed
24.
go back to reference Tirosh E, Bilker A, Bader D, Cohen A. Capnography in spontaneously breathing preterm and term infants. Clin Physiol. 2001;21(2):150–4.CrossRefPubMed Tirosh E, Bilker A, Bader D, Cohen A. Capnography in spontaneously breathing preterm and term infants. Clin Physiol. 2001;21(2):150–4.CrossRefPubMed
25.
go back to reference Tobias JD, Meyer DJ. Noninvasive monitoring of carbon dioxide during respiratory failure in toddlers and infants: end-tidal versus transcutaneous carbon dioxide. Anesth Analg. 1997;85(1):55–8.PubMed Tobias JD, Meyer DJ. Noninvasive monitoring of carbon dioxide during respiratory failure in toddlers and infants: end-tidal versus transcutaneous carbon dioxide. Anesth Analg. 1997;85(1):55–8.PubMed
26.
go back to reference Waugh JB, Epps CA, Khodneva YA. Capnography enhances surveillance of respiratory events during procedural sedation: a meta-analysis. J Clin Anesth. 2011. Waugh JB, Epps CA, Khodneva YA. Capnography enhances surveillance of respiratory events during procedural sedation: a meta-analysis. J Clin Anesth. 2011.
27.
go back to reference Wilson J, Russo P, Russo J, Tobias JD. Noninvasive monitoring of carbon dioxide in infants and children with congenital heart disease: end-tidal versus transcutaneous techniques. J Intensive Care Med. 2005;20(5):291–5.CrossRefPubMed Wilson J, Russo P, Russo J, Tobias JD. Noninvasive monitoring of carbon dioxide in infants and children with congenital heart disease: end-tidal versus transcutaneous techniques. J Intensive Care Med. 2005;20(5):291–5.CrossRefPubMed
28.
go back to reference Yarchi D, Cohen A, Umansky T, Sukhotnik I, Shaoul R. Assessment of end-tidal carbon dioxide during pediatric and adult sedation for endoscopic procedures. Gastrointest Endosc. 2009;69(4):877–82.CrossRefPubMed Yarchi D, Cohen A, Umansky T, Sukhotnik I, Shaoul R. Assessment of end-tidal carbon dioxide during pediatric and adult sedation for endoscopic procedures. Gastrointest Endosc. 2009;69(4):877–82.CrossRefPubMed
29.
go back to reference Yldzdas D, Yapcoglu H, Ylmaz HL. The value of capnography during sedation or sedation/analgesia in pediatric minor procedures. Pediatr Emerg Care. 2004;20(3):162–5.CrossRefPubMed Yldzdas D, Yapcoglu H, Ylmaz HL. The value of capnography during sedation or sedation/analgesia in pediatric minor procedures. Pediatr Emerg Care. 2004;20(3):162–5.CrossRefPubMed
30.
go back to reference Gozal Y, Gozal D. The Integrated Pulmonary Index: validity and application in the pediatric population. 2009. Gozal Y, Gozal D. The Integrated Pulmonary Index: validity and application in the pediatric population. 2009.
31.
go back to reference Gozal Y, Gozal D. Reliability of the Integrated Pulmonary Index Postoperatively. 2009. Gozal Y, Gozal D. Reliability of the Integrated Pulmonary Index Postoperatively. 2009.
32.
go back to reference Lightdale J, Fredette M, Atmadja M, Heard L, Jiang H. Pilot Study of the Smart Capnography Integrated Pulmonary IndexTM in a pediatric gastroenterology procedure unit. Gastrointest Endosc. 2010;71(5):AB255. Lightdale J, Fredette M, Atmadja M, Heard L, Jiang H. Pilot Study of the Smart Capnography Integrated Pulmonary IndexTM in a pediatric gastroenterology procedure unit. Gastrointest Endosc. 2010;71(5):AB255.
33.
go back to reference Sabbatani P, Mantovan R. Electrical cardioversion of atrial fibrillation: evaluation of sedation safety with midazolam by means of EtCO(2) and IPI algorithm analysis. Int J Cardiol. 2013;169(6):430–2.CrossRefPubMed Sabbatani P, Mantovan R. Electrical cardioversion of atrial fibrillation: evaluation of sedation safety with midazolam by means of EtCO(2) and IPI algorithm analysis. Int J Cardiol. 2013;169(6):430–2.CrossRefPubMed
34.
go back to reference Rusconi F, Castagneto M, Gagliardi L, Leo G, Pellegatta A, Porta N, Razon S, Braga M. Reference values for respiratory rate in the first 3 years of life. Pediatrics. 1994;94(3):350–5.PubMed Rusconi F, Castagneto M, Gagliardi L, Leo G, Pellegatta A, Porta N, Razon S, Braga M. Reference values for respiratory rate in the first 3 years of life. Pediatrics. 1994;94(3):350–5.PubMed
35.
go back to reference Wallis LA, Healy M, Undy MB, Maconochie I. Age related reference ranges for respiration rate and heart rate from 4 to 16 years. Arch Dis Child. 2005;90(11):1117–21.PubMedCentralCrossRefPubMed Wallis LA, Healy M, Undy MB, Maconochie I. Age related reference ranges for respiration rate and heart rate from 4 to 16 years. Arch Dis Child. 2005;90(11):1117–21.PubMedCentralCrossRefPubMed
36.
go back to reference National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring, Sept 29 to Oct 1, 1986. Pediatrics 1987;79(2):292–9. National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring, Sept 29 to Oct 1, 1986. Pediatrics 1987;79(2):292–9.
37.
go back to reference Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Paediatr Anaesth. 2008;18(1):9–10.PubMed Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Paediatr Anaesth. 2008;18(1):9–10.PubMed
38.
go back to reference Vargo JJ, Zuccaro G Jr, Dumot JA, Conwell DL, Morrow JB, Shay SS. Automated graphic assessment of respiratory activity is superior to pulse oximetry and visual assessment for the detection of early respiratory depression during therapeutic upper endoscopy. Gastrointest Endosc. 2002;55(7):826–31.CrossRefPubMed Vargo JJ, Zuccaro G Jr, Dumot JA, Conwell DL, Morrow JB, Shay SS. Automated graphic assessment of respiratory activity is superior to pulse oximetry and visual assessment for the detection of early respiratory depression during therapeutic upper endoscopy. Gastrointest Endosc. 2002;55(7):826–31.CrossRefPubMed
39.
go back to reference Elitsur Y, Blankenship P, Lawrence Z. Propofol sedation for endoscopic procedures in children. Endoscopy. 2000;32(10):788–91.CrossRefPubMed Elitsur Y, Blankenship P, Lawrence Z. Propofol sedation for endoscopic procedures in children. Endoscopy. 2000;32(10):788–91.CrossRefPubMed
40.
go back to reference VanNatta ME, Rex DK. Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol. 2006;101(10):2209–17.CrossRefPubMed VanNatta ME, Rex DK. Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol. 2006;101(10):2209–17.CrossRefPubMed
Metadata
Title
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children
Authors
Jamal Garah
Orly Eshach Adiv
Irit Rosen
Ron Shaoul
Publication date
01-12-2015
Publisher
Springer Netherlands
Published in
Journal of Clinical Monitoring and Computing / Issue 6/2015
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI
https://doi.org/10.1007/s10877-015-9665-z

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