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BMC Medical Research Methodology
Published in: BMC Medical Research Methodology 1/2011

Open Access 01-12-2011 | Research article

The validation of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) in pre-operative patients with brain tumor in China

Authors: Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Yong-qiang Zhang, Wei Lin, Rui Wang, Yong-qin Zhang, Hong-ying Zhang, Li Xie, Jun-li Huo

Published in: BMC Medical Research Methodology | Issue 1/2011

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Abstract

Background

Health related quality of life (HRQOL) has increasingly emphasized on cancer patients. The psychometric properties of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0) in brain tumor patients wasn't proven, and there was no baseline HRQOL in brain tumor patients prior to surgery.

Methods

The questionnaire EORTC QLQ-C30 (version 3.0) was administered at three time points: T1, the first or the second day that patients were hospitalized after the brain tumor suspected or diagnosed by MRI or CT; T2, 1 to 2 days after T1, (T1 and T2 were both before surgery); T3, the day before discharge. Clinical variables included disease histologic types, cognitive function, and Karnofsky Performance Status.

Results

Cronbach's alpha coefficients for multi-item scales were greater than .70 and multitrait scaling analysis showed that most of the item-scale correlation coefficients met the standards of convergent and discriminant validity, except for the cognitive functioning scale. All scales and items exhibited construct validity. Score changes over peri-operation were observed in physical and role functioning scales. Compared with mixed cancer patients assessed after surgery but before adjuvant treatment, brain tumor patients assessed pre-surgery presented better function and fewer symptoms.

Conclusions

The standard Chinese version of the EORTC QLQ-C30 was overall a valid instrument to assess HRQOL in brain tumor patients in China. The baseline HRQOL in brain tumor patients pre-surgery was better than that in mixed cancer patients post-surgery. Future study should modify cognitive functioning scale and examine test-retest reliability and response validity.
Appendix
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Metadata
Title
The validation of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) in pre-operative patients with brain tumor in China
Authors
Jin-xiang Cheng
Bo-lin Liu
Xiang Zhang
Yong-qiang Zhang
Wei Lin
Rui Wang
Yong-qin Zhang
Hong-ying Zhang
Li Xie
Jun-li Huo
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Medical Research Methodology / Issue 1/2011
Electronic ISSN: 1471-2288
DOI
https://doi.org/10.1186/1471-2288-11-56

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