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Open Access 01-12-2018 | Protocol

The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol

Authors: Patricia M. Fortes, Solomar M. Marques, Karolline A. Viana, Luciane R. Costa, Alessandra V. Naghettini, Paulo Sucasas Costa

Published in: Systematic Reviews | Issue 1/2018

Abstract

Background

Dyslipidemia is a major risk factor in triggering cardiovascular events, which can lead to the death of millions of people around the world. Thus, several pharmacological and non-pharmacological therapeutic strategies have been developed in recent decades with the objective of improving lipid profiles, including the use of probiotics. Therefore, the purpose of this protocol is to describe the steps that will guide the construction of an overview to demonstrate the scientific evidence of the efficacy of probiotics in improving the lipid profile of dyslipidemic individuals and to propose specific recommendations regarding their use.

Methods

The search will be conducted in the following databases: MEDLINE/PubMed, EMBASE, PROSPERO, Cochrane Library, CINAHL, JBI Database of Systematic Reviews and Implementation Reports, Google Scholar, and CADTH. Reviewers will select systematic evaluations and data analyses from randomized clinical trials that evaluated the effects of probiotics on lipid profiles. The studies will be analyzed for methodology quality by the AMSTAR 2 tool and risk of bias by ROBIS. The data will be extracted by three independent reviewers based on a data extraction sheet, which will include the most relevant variables for the analysis and interpretation of the results. The variables will be categorized and described in narrative form or in tables.

Discussion

There are some systematic reviews about the use of probiotics to prevent and/or treat dyslipidemia; however, their outcomes related to the ability of probiotics to improve lipid profiles are conflicting. So, an overview on this topic is needed to clarify this important issue.

Systematic review registration

PROSPERO CRD42017080328

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Title: The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol
Authors: Patricia M. Fortes
Solomar M. Marques
Karolline A. Viana
Luciane R. Costa
Alessandra V. Naghettini
Paulo Sucasas Costa
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Systematic Reviews / Issue 1/2018
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-018-0826-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol

Abstract

Background

Methods

Discussion

Systematic review registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Discussion

Systematic review registration

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