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Journal of Cardiothoracic Surgery

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Open Access 01-12-2013 | Research article

The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy

Authors: Sang Kwon Lee, Bong Soo Son, Jung Joo Hwang, Kil Dong Kim, Do Hyung Kim

Published in: Journal of Cardiothoracic Surgery | Issue 1/2013

Abstract

Background

The prognosis of acute lung injury (ALI) after pneumonectomy is poor, with reported mortality rates of 30-100%. Neutrophil elastase inhibitor (NEI) is known to prevent lung injury caused by neutrophil elastase and improve lung function in ALI. We evaluated the effect of NEI on ALI after pneumonectomy.

Methods

We analyzed nine patients who required ventilator care due to ALI after pneumonectomy. Five of these patients underwent conventional ventilator care (group I), and four patients underwent ventilator care and were administrated NEI (group II). We retrospectively analyzed the lung injury score (LIS) for 10 days after intubation.

Results

The LIS before intubation satisfied the diagnostic criteria of ALI or acute respiratory distress syndrome (ARDS) in all patients. After intubation, the LIS improved in both groups. But, as times went on, the mean value of the LIS in group II was lower compared to group I. In group I, only one patient underwent extubation. In group II, extubation was possible in three patients. Mortality rates were 80% in group I and 25% in group II.

Conclusions

We conclude that NEI may improve the lung function, shorten the duration of mechanical ventilation, and reduce mortality in patients with ALI after pneumonectomy.

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Title: The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy
Authors: Sang Kwon Lee
Bong Soo Son
Jung Joo Hwang
Kil Dong Kim
Do Hyung Kim
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Journal of Cardiothoracic Surgery / Issue 1/2013
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/1749-8090-8-69

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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