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01-12-2008 | Original Article

The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients

Authors: E. Brannon Morris, John Shelso, Matthew P. Smeltzer, Nicole A. Thomas, E. Jane Karimova, Chin-Shang Li, Thomas Merchant, Amar Gajjar, Sue C. Kaste

Published in: Pediatric Radiology | Issue 12/2008

Abstract

Background

Skeletal bone accretion occurs throughout childhood. The integrity of this process can influence future adult bone health and the risk of osteoporosis. Although surveillance of children who are at risk of poor bone accretion is important, the most appropriate method to monitor childhood bone health has not been established. Previous investigators have proposed using bone age (BA) rather than chronological age (CA) when interpreting bone mineral density (BMD) values in children.

Objective

To investigate the value of BA assessment for BMD measurement in a cohort of children at risk of poor accretion.

Materials and methods

A cohort of 163 children with brain tumors who completed both a BMD assessment (quantitative computed tomography, QCT) and who had a BA within a 6-month interval were identified. The difference in BMD Z-scores determined by CA and BA was determined. The impact of salient clinical features was assessed.

Results

No significant difference between CA and BA Z-scores was detected in the overall cohort (P = 0.056). However, the scores in 18 children (all boys between the ages of 11 years and 15 years) were statistically determined to be outliers from the values in the rest of the cohort.

Conclusion

Interpretation of BMD with BA measurement might be appropriate and affect treatment decisions in peripubertal males.

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Title: The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients
Authors: E. Brannon Morris
John Shelso
Matthew P. Smeltzer
Nicole A. Thomas
E. Jane Karimova
Chin-Shang Li
Thomas Merchant
Amar Gajjar
Sue C. Kaste
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 12/2008
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-008-0991-x

2024 ASCO Annual Meeting

Springer Medicine

The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients

Abstract

Background

Objective

Materials and methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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