Skip to main content
Top
Published in: Trials 1/2011

Open Access 01-12-2011 | Research

The UK clinical research network - has it been a success for dermatology clinical trials?

Authors: Kim S Thomas, Karin Koller, Katharine Foster, Jo Perdue, Lisa Charlesworth, Joanne R Chalmers

Published in: Trials | Issue 1/2011

Login to get access

Abstract

Background

Following the successful introduction of five topic-specific research networks in the UK, the Comprehensive Local Research Network (CLRN) was established in 2008 in order to provide a blanket level of support across the whole country regardless of the clinical discipline. The role of the CLRN was to facilitate recruitment into clinical trials, and to encourage greater engagement in research throughout the National Health Service (NHS).

Methods

This report evaluates the impact of clinical research networks in supporting clinical trials in the UK, with particular reference to our experiences from two non-commercial dermatology trials. It covers our experience of engaging with the CLRN (and other research networks) using two non-commercial dermatology trials as case studies. We present the circumstances that led to our approach to the research networks for support, and the impact that this support had on the delivery of these trials.

Results

In both cases, recruitment was boosted considerably following the provision of additional support, although other factors such as the availability of experienced personnel, and the role of advertising and media coverage in promoting the trials were also important in translating this additional resource into increased recruitment.

Conclusions

Recruitment into clinical trials is a complex task that can be influenced by many factors. A world-class clinical research infrastructure is now in place in England (with similar support available in Scotland and Wales), and it is the responsibility of the research community to ensure that this unique resource is used effectively and responsibly.
Appendix
Available only for authorised users
Literature
1.
go back to reference Best Research for Best Health - A new national health research strategy (272605). 2006, Department of Health Best Research for Best Health - A new national health research strategy (272605). 2006, Department of Health
2.
go back to reference Thomas KS, Dean T, O'Leary C, Sach TH, Koller K, Frost A: A Randomised Controlled Trial of Ion-Exchange Water Softeners for the Treatment of Eczema in Children. PLoS Med. 2011, 8 (2): e1000395-10.1371/journal.pmed.1000395.CrossRefPubMedPubMedCentral Thomas KS, Dean T, O'Leary C, Sach TH, Koller K, Frost A: A Randomised Controlled Trial of Ion-Exchange Water Softeners for the Treatment of Eczema in Children. PLoS Med. 2011, 8 (2): e1000395-10.1371/journal.pmed.1000395.CrossRefPubMedPubMedCentral
3.
go back to reference Thomas K, Koller K, Dean T, Gilbert C, Sach TH, Frost A: A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET). 2011, Health Technol Assess, 15 (8): Thomas K, Koller K, Dean T, Gilbert C, Sach TH, Frost A: A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET). 2011, Health Technol Assess, 15 (8):
5.
go back to reference Thomas KS, UK Dermatology Clinical Trials Network's PATCH study group: Studying a disease with no home--lessons in trial recruitment from the PATCH II study. Trials [Electronic Resource]. 2010, 11: 22- Thomas KS, UK Dermatology Clinical Trials Network's PATCH study group: Studying a disease with no home--lessons in trial recruitment from the PATCH II study. Trials [Electronic Resource]. 2010, 11: 22-
8.
go back to reference Clarke M, Loudon K: Effects on patients of their healthcare practitioner's or institution's participation in clinical trials: a systematic review. Trials. 2011, 12 (16): Clarke M, Loudon K: Effects on patients of their healthcare practitioner's or institution's participation in clinical trials: a systematic review. Trials. 2011, 12 (16):
Metadata
Title
The UK clinical research network - has it been a success for dermatology clinical trials?
Authors
Kim S Thomas
Karin Koller
Katharine Foster
Jo Perdue
Lisa Charlesworth
Joanne R Chalmers
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Trials / Issue 1/2011
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-12-153

Other articles of this Issue 1/2011

Trials 1/2011 Go to the issue