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Open Access 01-10-2008 | Educational Feature

The thrombotic microangiopathies

Authors: Lawrence Copelovitch, Bernard S. Kaplan

Published in: Pediatric Nephrology | Issue 10/2008

Abstract

The term thrombotic microangiopathy (TMA) encompasses a group of conditions that are defined by, or result from, a similar histopathological lesion. Hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and several other conditions are associated with TMA. Distinguishing HUS from TTP is not always possible unless there are specific causes, such as Shiga toxin, Streptococcus pneumoniae, or a specific molecular defect such as factor H or ADAMTS13 deficiency. This review describes the forms of HUS/TTP that are not related to Shiga toxin, pneumococcal infection, genetic causes, or ADAMTS13 deficiency. Conditions include HUS/TTP associated with autoimmune disorders, human immunodeficiency virus (HIV) infection, transplantation, malignancy, and medications.

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Title: The thrombotic microangiopathies
Authors: Lawrence Copelovitch
Bernard S. Kaplan
Publication date: 01-10-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0616-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The thrombotic microangiopathies

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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