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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2019

Open Access 01-12-2019 | Research article

The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016

Authors: Xi Wang, Yujie Ning, Amin Liu, Xin Qi, Meidan Liu, Pan Zhang, Xiong Guo

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

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Abstract

Background

Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China.

Methods

For this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool.

Results

A total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8–15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6–17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7–20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5–12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD.

Conclusions

Our systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD.
Appendix
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Literature
1.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthr Cartil. 2014;22:1774–83.CrossRef
2.
The National Health Commission of China. The prevention and control status of Kashin-Beck disease in 2017.
3.
Xiong G. Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop. 2001;25:147–50.CrossRef
4.
Wang X, Zhang P, Ning Y, Yang L, Yu F, Guo X. Serum and hair zinc levels in patients with endemic Osteochondropathy in China: A meta-analysis. Biol Trace Elem Res. 2017.
5.
group NKBdm. Report of a National Survey of Kashin-Beck disease prevalence in 2005. Chinese Journal of Endemiology. 2006;25:670–2.
6.
Liu H, Zhou LW, YQ L. Analysis of National Surveillance on Kashin-Beck disease condition from 2000 to 2007. Chinese Journal of Endemiology. 2009;28:554–6.
7.
Panic N, Leoncini E, de Belvis G, Ricciardi W, Boccia S. Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PLoS One. 2013;8:e83138.CrossRef
8.
Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health. 2014;72:39.CrossRef
9.
Borenstein M, Hedges LV, Higgins JP, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1:97–111.CrossRef
10.
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.CrossRef
11.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.CrossRef
12.
Zhang CN, Zhang W. ZS. N. Summary of 14 years' monitoring of Kaschin - Beck disease in Heilongjiang province. Chinese journal of control of endemic. Diseases. 2005;20:161–3.
13.
Su HM, Qiao H. Y L. analysis of monitoring results of Kaschin - Beck disease in Songyuan from 2009 to 2011. Chinese journal of control of endemic. Diseases. 2012;27:142–3.
14.
H T. Analysis of monitoring results of Kaschin - Beck disease in Erdos City in 2011. Inner Mongolia Medical Journal. 2012;44:24–5.
15.
Xun IH, Wang Q, Yu YF. JY C. Analysis of 17 - year monitoring results of Kashin - Beck disease in Wushenqi of inner. Inner Mongolia medical. Journal. 2009;41:211–3.
16.
Xun IH, Wang Q, Yu YF. JY C. Surveillance of Kashin - Beck disease in Nalin River township, Wushenqi, Inner Mongolia from 2000 to 2006. Inner Mongolia medical. Journal. 2007;39:621–2.
17.
Yuan F, JX Z. Current status and dynamics of Kaschin - Beck disease in Huanqi Lingdong Si qi city. Inner Mongolia. Prev Med. 1998;23:13–4.
18.
Yuan F, Jx Z. Present situation and dynamic analysis of Kashin Beck disease in Hulun Buir league. Chinese journal of control of endemic Diseases. 1998;13:162–3.
19.
Liu QB, Liu XH, Zhang JX, Wang G, Fan J, Liu XB, et al. Evaluation of the effect of changing food for the prevention of Kaschin - Beck disease in Hulunbeier league, inner. Chinese Journal of Endemiology. 2002;21:117–9.
20.
Zhang JX, JG Z. 1990-1994 report of Huakao Kashin-Beck disease. Study on Prevention and Control of Endemic Diseases in Inner. 1995;20:125–6.
21.
Zhou JC, Zhang MQ. C L. study on the evaluation model for eliminating Kashin - Beck disease in Huairou district ,Beijing. Chinese journal of control of endemic. Diseases. 2013;28:283–4.
22.
Wang JR, Zhang J, HR C. Dynamic observation and analysis of Kashin - Beck disease in Chunhua County of Shaanxi Province. Studies of Trace Elements and Health. 2011;28:37–8.CrossRef
23.
Yu YH, Cui CL. YT Y. Prevalence of Kashin - Beck disease in Henan Province. Henan. J Prev Med. 2011;22:237–8.
24.
Yu HY, Xing HX, Yang GM, Cui CL, Standard PXH. Range of selenium concentration in selenium iodide in Kaschin disease and Keshan disease area in Henan province. Henan Journal of Preventive Medicine. 2001;12:260–51.
25.
Yang WZ, Wang DS, Wang YC, Wu XJ, Bai JC, Surveillance JMZ. Analysis of Kashin - Beck disease in Shanxian County of Henan Province. Henan Journal of Preventive Medicine. 1994;5:95–6.
26.
HJ W. Report on 32 - year monitoring of Kaschin - Beck disease in Beijing. Medical Journal of Chinese People's Health. 2011;23:1481–2.
27.
He XQ. M Z. Surveillance and analysis of prevention and treatment of Kashin - Beck disease in Nanzheng County of Shaanxi Province in the past 20 years. Journal of Preventive Medicine of Anhui Province. 2010;16:180–1.
28.
Xie L, Chen W, Jin L, Yang G. PJ Y. Monitoring report of Kashin - Beck disease and selenium in 2007 and 2008. Modern Preventive Medicine. 2010;37:924–5.
29.
Xie L, Chen W, Jin L. G Y. Analysis of monitoring results of Kaschin - Beck disease in Xi'an from 2006 to 2007. Chinese journal of control of endemic. Diseases. 2008;23:307–8.
30.
Lv XY, Xu GY. P C. Report on monitoring of KasChin - Beck disease in Shaanxi Province in 2007. Chinese journal of control of endemic. Diseases. 2009;24:309–10.
31.
Xu GY, Cao XG, XY L. Report of Kaschin-Beck disease prevalence and selenium salt monitoring in Shaanxi province from 2001 to 2003. Chin J End. 2004;23:556–7.
32.
Cao XG, Zhang BD, Qin ZR, Lv XY, Xu GY, Liu HL, et al. The monitoring report of Kaschin-Beck disease prevalence rate in Yuyang county of Shaanxi. Chin J End. 2004;23:369–70.
33.
Yang G, Chen W, Xie L. L J. Surveillance Report of Kaschin - Beck Disease in Jinjing Village, Zhouzhi County, Xi'an, from 2001 to 2003. Chin J End. 2005;24:704.
34.
Wang FQ. ZW W. Surveillance report of Kaschin-Beck disease from 1996 to 2000 in Linyou County, Shaanxi Province. Endemic Diseases Bulletin. 2001;16:65.
35.
Chen W, Yang G, Jing L, Yao PJ. L X. Analysis on monitoring results of Kaschin-Beck disease flow monitoring points in Xi'an from 2001 to 2002. Occupation and Health. 2004;20:79–80.
36.
Sun J, Che WF, Han W, Wu YX, Xu JF, BK W. An investigation on the relation between improvement of Kaschin-Beck disease and Enviornmental selenium level. Endemic Diseases Bulletin. 1992;7:16–8.
37.
Xu GY, Cao XG, XY L. Anaiysis on monitoring data of Kaschin-Beck disease in shannxi province during l9 years. Chin J End. 2009;24:442–6.
38.
Xie L, Chen W, Jing L, Yang G. PJ Y. Anaiysis on monitoring results of Kaschin-Beck disease in LanTian county of Xi'an city from 2001 to 2008. Modern Preventive Medicine. 2011;38:2382–4.
39.
Lv XY, Xu GY, Liang ST, Zhang BD, Ma CA, Zhu CS, et al. Comprehensive prevention and control of Kaschin-Beck disease in Binxian County of Shaanxi Province. Endemic Diseases Bulletin. 2002;17:62–3.
40.
Zhang BD, Ma CA, Lv XY, Xu GY. G D. Analysis and investigation of Kaschin - Beck disease prevalence rate in Yuyang county of Shaanxi province. Chinese Journal of Endemiology. 2002;21:371–3.
41.
Yi BT, Wen J, Yang JY, Hu CG, L Y. Analysis of monitoring results of KBD among children aged7–12 in Ningshan County 2004–2014. Foreign Medical Sciences (Section of Medgeography). 2016; 36:237–38.
42.
Cui DF. XP H. Analysis of monitoring results of Kaschin-Beck disease in Qingyang City. Bulletin of disease control and. Prevention. 2013;28:40.
43.
Ge PF, Bo SY, Xu JM, Wang WL, Jia JX, YG R. Analysis of Surveillance results of Kaschin-Beck disease in Gansu province in 2003 and 2004. Endemic Diseases Bulletin. 2008;23:43–5.
44.
Liu FS, Ma MZ, Lei CY, Wang HW, Zheng WZ, Yang YM, et al. Investigation report on Kaschin-Beck disease in Tianshui City, Gansu Province, 2002-2003. Endemic Diseases Bulletin. 2007;22:47–9.
45.
Zhang YQ, Liang CZ, Yin XJ, Lai XQ, Zhao YH. XY S. Analysis of surveillance of Kaschin-Beck disease in Dingxi City of Gansu Province. Bulletin of disease control and. Prevention. 2014;29:28–9.
46.
Bai SQ. LL G. Effect of selenium supplementation on prevention and treatment of Kaschin-Beck disease in Tongchuan County, Gansu Province for 20 years. Endemic Diseases Bulletin. 2002;17:40–2.
47.
Luo YH. YQ Z. Analysis of monitoring results of Kaschin-Beck disease in Dingxi City from 2008 to 2010. Health vocational. Education. 2012;34:122–3.
48.
Li Q, Zhao ZJ, Wen H. P Y. Observation of KBD prevalence state in two national monitoring points from 1999 to 2003. Chinese journal of. Infect Control. 2004;19:352–4.
49.
Ding SR, Wen H, Li Q, Wan DZX, Ren ZZX, Liu CZ, et al. Analysis on the state of Kaschin-Beck disease from 1989 to 2000 in Xinhai county Qinhai province. Chinese Journal of Endemiology. 2001;20:372–4.
50.
SR D. Analysis on the state of Kaschin-Beck diease from 1992 to 2001 in guide county Qinhai province. Chinese Journal of Endemiology. 2003;22:148–9.
51.
Li Q, ZJ Z. Prevalence state of Kashin-Beck disease in Qinghai Province:a retrospective analysis. Chinese Journal of Endemiology. 2006;25:675–7.
52.
Bao JQ, Wan DZX, MJ Z. Analysis of Kashin - Beck disease in Xinghai County of Qinghai Province from 1995 to 1997. Endemic Diseases Bulletin. 1998;13:50–5.
53.
Li Q, Wen H, Ding SR. YP C. Surveillance report of Kashin - Beck disease from 1998 to 2000 in Xinghai County, Qinghai Province. Endemic Diseases Bulletin. 2002;17:57–8.
54.
Zhao SC, Gong HQ, Guo M, Ni MCJ, De JYZ. QW L. analysis on prevalence trend of Kashin- Beck disease in Tibet from 2000 to 2015. Chinese journal of control of endemic. Diseases. 2016;31:841–4.
55.
Gong HQ, Zha XSZ, Bai MCW, SDJ G. Observation on the effect of iodine - selenium salt in prevention and cure of Kashin - Beck disease in Xietongmen County. Endemic Diseases Bulletin. 2004;19:61–2.
56.
DNY A, Xu G, Wang SY, Cong MY, Qin SC, My Y. Analysis on monitoring results of Kashinyin aba state of Sichuan Province. Journal of MUC( Natural Sciences Edition). 2015;24:93–6.
57.
Wang YG, Deng JY. DY L. 22 -year dynamic monitoring of Kashin - Beck disease in Aba County. Journal of Preventive Medicine Information. 2005;21:94–6.
58.
Zhang XC, Lu CR. HP W. Analysis on the survey of Kashin - Beck disease in Pingwu County from 2006 to 2009. Parasitoses Infect Dis. 2009;7:164–5.
59.
Li DW, Wang ZS, Luo YG, Cao ZF, Li XL. DY C. Major factors influencing the state of Kaschin-Beck disease in Hanyuan County, Sichuan Province. Chinese Journal of Endemiology. 2003;22:150–1.
60.
Deng JY, Li FZ. H H. Current situation and trend of Kaschin-Beck disease in Sichuan Province. Journal of Preventive Medicine Information. 2008;24:762–5.
61.
Huang H, Li FZ, Deng JY, Li JS. P Y. Investigation results of Kashin-Beck disease in Sichuan Province, 2005- 2009. Journal of Preventive Medicine Information. 2010;26:966–8.
62.
Deng JY, Li DY, Cai W, Zhu L, Liang DH, Gu Y, et al. Analysis on the data of surveillance for KBD and hair selenium level. Chinese Journal of Endemiology. 1999;18:442–4.
Metadata
Title
The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016
Authors
Xi Wang
Yujie Ning
Amin Liu
Xin Qi
Meidan Liu
Pan Zhang
Xiong Guo
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-019-2461-z

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