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Open Access 01-04-2017 | Original Contributions

The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume

Authors: Nasreen A. Vohra, Swapnil D. Kachare, Paul Vos, Bruce F. Schroeder, Olga Schuth, Dylan Suttle, Timothy L. Fitzgerald, Jan H. Wong, Kathryn M. Verbanac

Published in: Obesity Surgery | Issue 4/2017

Abstract

Purpose

Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods.

Materials and Methods

Fibroglandular volume, breast volume, and their ratio, the VBD, were calculated from mammograms before and after WLS by using Volpara™ automated software.

Results

For the 80 women included, average body mass index decreased from 46.0 ± 7.22 to 33.7 ± 7.06 kg/m². Mammograms were performed on average 11.6 ± 9.4 months before and 10.1 ± 7 months after WLS. There was a significant reduction in average breast volume (39.4 % decrease) and average fibroglandular volume (15.5 % decrease), and thus, the average VBD increased from 5.15 to 7.87 % (p < 1 × 10⁻⁹) after WLS. When stratified by menopausal status and diabetic status, VBD increased significantly in all groups but only perimenopausal and postmenopausal women and non-diabetics experienced a significant reduction in fibroglandular volume.

Conclusions

Breast volume and fibroglandular volume decreased, and VBD increased following WLS, with the most significant change observed in postmenopausal women and non-diabetics. Further studies are warranted to determine how physical and biological alterations in breast density components after WLS may impact breast cancer risk.

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Title: The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume
Authors: Nasreen A. Vohra
Swapnil D. Kachare
Paul Vos
Bruce F. Schroeder
Olga Schuth
Dylan Suttle
Timothy L. Fitzgerald
Jan H. Wong
Kathryn M. Verbanac
Publication date: 01-04-2017
Publisher: Springer US
Published in: Obesity Surgery / Issue 4/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-016-2415-6

At a glance: The STEP trials

Springer Medicine

The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume

Abstract

Purpose

Materials and Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusions

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