Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2016

Open Access 01-12-2016 | Research article

The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases

Authors: Ozlem Sahin, Alireza Ziaei, Eda Karaismailoğlu, Nusret Taheri

Published in: BMC Ophthalmology | Issue 1/2016

Login to get access

Abstract

Background

Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.

Methods

This is a prospective study involving patients with ankylosing spondylitis, behcet’s disease, presumed sarcoidosis, presumed latent tuberculosis, presumed latent syphilis, and control group. The serum levels of angiotensin converting enzyme and lysozyme were analyzed by enzyme-linked immunosorbent assay. Bonnferoni analysis was used to assess pairwise comparisons between the groups.

Results

There was a significant increase in serum angiotensin converting enzyme level in patients with presumed sarcoidosis compared to ankylosing spondylitis (p = 0.0001), behcet’s disease (p = 0.0001), presumed latent tuberculosis (p = 0.0001), presumed latent syphilis (p = 0.0001), and control group (p = 0.0001). The increase in serum lysozyme level was significant for patients with presumed sarcoidosis with respect to ankylosing spondylitis (p = 0.0001), behcet’s disease, (p = 0.0001) presumed latent tuberculosis (p = 0.001), presumed latent syphilis (p = 0.033), and control group (p = 0.0001).

Conclusion

Elevated serum angiotensin converting enzyme levels are significant for patients with presumed sarcoidosis compared to ocular involvement of other autoimmune diseases such as behcet’s disease and ankylosing spondylitis, and ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis. However, elevated serum lysozyme level might be also detected in ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis.

Trial registration

Trial Registration number: NCT02627209. Date of registration: 12/09/2015.
Literature
1.
Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal programming, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014;4:201.
2.
Miyazaki A, Kitaichi N, Ohgami K, Iwata D, Jin XH, Iwabuchi K, et al. Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Graefes Arch Clin Exp Ophthalmol. 2008;246:747–57.CrossRefPubMed
3.
4.
5.
Mulak M, Misiuk-Hojlo M, Slowik M. The behavior of angiotensin converting enzyme in patients with uveitis. Klin Oczna. 1999;101:5–8.PubMed
6.
Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan degrading property of lysozyme is not required for bacteriocidal activity in vivo. J Immunol. 2006;177:519–26.CrossRefPubMed
7.
Majcherczyk PA, Langen H, Heumann M, Fountoulakis M, Glauser P, Moreillion P. Digestion of Streptococcus pneumonia cell walls with its major peptidoglycan hydrolase releases branched stem peptides carrying proinflammatory activity. J Biol Chem. 1999;274:12537–43.CrossRefPubMed
8.
Sen DK, Sarin GS. Immunoassay of serum muramidase (lysozyme) in ocular diseases. Indian J Ophthalmol. 1987;35:103–7.PubMed
9.
Herbort CP, Rao NA, Mochizuki M, members of Scientific Committee of First International Workshop on ocular sarcoidosis. International criteria for the diagnosis of ocular sarcoidosis: results of the first ınternational Workshop on ocular sarcoidosis (IWOS). Ocul Immunol Inflamm. 2009;17:160–9.CrossRefPubMed
10.
[No authors listed] Evaluation of the diagnostic (‘classification’) criteria in Behcet’s disease-towards internationally agreed criteria. The International Study Group for Behcet’s disease. Br J Rheumatol 1992;31:299–308.
11.
Morshed MG. Current trend on syphilis diagnosis: issues and challenges. Adv Exp Med Biol. 2014;808:51–64.CrossRefPubMed
12.
Beneteau B, Baudin B, Morgant G, Giboudeau J, Baumann FC. Automated kinetic assay of angiotensin-converting enzyme in serum. Clin Chem. 1986;32:884–6.PubMed
13.
Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965;2:235–54.CrossRefPubMed
14.
Takeuchi M, Oh-I K, Suzuki J, Hattori D, Takeuchi A, Okunuki Y, et al. Elevated serum levels of CXCL9/monokine induced by interferon- Gamma and CXCL10/interferon gamma-inducible protein-10 in ocular sarcoidosis. Invest Ophthalmol Vis Sci. 2006;47:1063–8.CrossRefPubMed
15.
Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 1994;84:4008–27.PubMed
16.
Murdoch C, Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood. 2000;95:3032–43.PubMed
17.
18.
Ichimura S et al. Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin Exp Immunol. 2003;132:152–7.CrossRef
19.
Stavrou P, Linton S, Young DW, Murray PI. Clinical diagnosis of ocular sarcoidosis. Eye (Lond). 1997;11:365–70.CrossRef
20.
Weinreb RN, O’Donnell JJ, Sandman R, Char DH, Kimura SJ. Angiotensin-converting enzyme in sarcoid uveitis. Invest Ophthalmol Vis Sci. 1979;18:1285–7.PubMed
21.
Power WJ, Neves RA, Rodriquez A, Pedrosa-Seres M, Foster CS. The value of combined serum angiotensin-converting enzyme and gallium scan in diagnosing ocular sarcoidosis. Ophthalmology. 1995;102:2007–11.CrossRefPubMed
22.
Deverriere G, Flamans-Klein A, Firmin D, Azouzi O, Courville P, Le Roux P. Early onset pediatric sarcoidosis, diagnostic problems. Arch Pediatr. 2012;19:707–10.CrossRefPubMed
23.
Hunninghake GW, Costabel U, Ando M, Baughman R, Cordier JF, du Bois R, et al. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999;16:149–73.PubMed
24.
Adamovich VN, Borisov SE, Zubkov AA, Danilov SM, Sakharov II, Atochina EN. Serum angiotensin converting enzyme in the diagnosis of sarcoidosis and other lung diseases. Probl Tuberk. 1991;10:18–22.PubMed
25.
Fukami R, Ohba S, Ishida K, Nakamura S, Konno M, Ohno S. Serum adenosine deaminase and angiotensin converting enzyme activity in patients with endogenous uveitis. Nihon Ganka Gakkai Zasshi. 1994;98:287–92.PubMed
26.
Lowe JR, Dixon JS, Guthrie JA, McWhinney P. Serum and synovial fluid levels of angiotensin converting enzyme in polyarthritis. Ann Rheum Dis. 1986;45:921–4.PubMedCentralCrossRefPubMed
27.
Tomita H, Sato S, Matsuda R, Suquira R, Kawaquichi H, Niimi T, et al. Serum lysozyme levels and clinical features of sarcoidosis. Lung. 1999;177:161–7.CrossRefPubMed
28.
Birnbaum AD, Oh FS, Chakrabarti A, Tessler HH, Goldstein DA. Clinical features and diagnostic evaluation of biopsy-proven ocular sarcoidosis. Arch Ophthalmol. 2011;129:409–13.CrossRefPubMed
29.
Baarsma GS, La Hey E, Glasius E, de Vries J, Kijlstra A. The predictive value of serum angiotensin converting enzyme and lysozyme levels in the diagnosis of ocular sarcoidosis. Am J Ophthalmol. 1987;104:211–7.CrossRefPubMed
Metadata
Title
The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases
Authors
Ozlem Sahin
Alireza Ziaei
Eda Karaismailoğlu
Nusret Taheri
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2016
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-016-0194-4

Other articles of this Issue 1/2016

BMC Ophthalmology 1/2016 Go to the issue

Research article

Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia

Case report

Chronic post-operative iris prosthesis endophthalmitis in a patient with traumatic aniridia: a case report

Research article

Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment

Case report

Acute multifocal hemorrhagic retinal vasculitis in a child: a case report

Research article

Functional improvement assessed by multifocal electroretinogram after Ocriplasmin treatment for vitreomacular traction

Research article

Selective laser trabeculoplasty for early glaucoma: analysis of success predictors and adjusted laser outcomes based on the untreated fellow eye