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01-12-2009 | Original Article

The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome

Authors: Ruth Kohen, Monica E. Jarrett, Kevin C. Cain, Sang-Eun Jun, Grace P. Navaja, Sarah Symonds, Margaret M. Heitkemper

Published in: Digestive Diseases and Sciences | Issue 12/2009

Abstract

Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology. The serotonin transporter regulates the intensity and duration of serotonin signaling in the gut and is, therefore, an attractive candidate gene for irritable bowel syndrome. Previous studies investigating the 5-HTTLPR and Stin2 VNTR polymorphisms of the serotonin transporter have proved inconclusive. In this exploratory study we therefore expanded the search for a possible association of the serotonin transporter with irritable bowel syndrome to include not only the 5-HTTLPR and Stin2 VNTR length polymorphisms, but also the functional single nucleotide polymorphism rs25531. We genotyped 186 patients with irritable bowel syndrome and 50 healthy control subjects raging in age from 18 to 70 years. Carriers of the rare G allele of rs25531 had approximately threefold increased odds of irritable bowel syndrome compared with healthy controls (OR 3.3, 95% CI 1.1–9.6). Our findings suggest that further investigation of the possible role of the serotonin transporter in the etiology of IBS is warranted.

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Title: The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome
Authors: Ruth Kohen
Monica E. Jarrett
Kevin C. Cain
Sang-Eun Jun
Grace P. Navaja
Sarah Symonds
Margaret M. Heitkemper
Publication date: 01-12-2009
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 12/2009
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0666-3

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