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Obesity Surgery
Published in: Obesity Surgery 1/2008

01-01-2008 | Research Article

The Serial Changes of Ghrelin and Leptin Levels and Their Relations to Weight Loss After Laparoscopic Minigastric Bypass Surgery

Authors: Jyh-Ming Liou, Jaw-Town Lin, Wei-Jei Lee, Hsiu-Po Wang, Yi-Chia Lee, Han-Mo Chiu, Ming-Shiang Wu

Published in: Obesity Surgery | Issue 1/2008

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Abstract

Background

The ghrelin and leptin levels have been reported to be correlated with weight loss after bariatric surgery. However, the serial changes of ghrelin and leptin levels after laparoscopic minigastric bypass surgery (LMGBP) have not been reported yet. Therefore, we aimed to evaluate their serial changes and to analyze their relations to weight reduction after LMGBP.

Methods

Serial fasting serum leptin and ghrelin concentrations were measured in 68 morbidly obese patients before (M0) and 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months after LMGBP surgery. The correlations between ghrelin, insulin, and leptin concentrations and weight reduction were analyzed.

Results

Leptin levels were significantly reduced at 1, 3, 6, and 12 months after surgery, respectively (vs M0, p < 0.001), whereas the ghrelin concentrations were not significantly changed after surgery. The percent of excess BMI lost (%EBL) 12 months after surgery was negatively correlated with higher preoperative ghrelin concentrations (p = 0.004) and larger preoperative BMI (p = 0.002) in the multivariate analysis.

Conclusion

Higher preoperative ghrelin concentrations and larger BMI are predictive of less %EBL at 12 months after LMGBP surgery.
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Metadata
Title
The Serial Changes of Ghrelin and Leptin Levels and Their Relations to Weight Loss After Laparoscopic Minigastric Bypass Surgery
Authors
Jyh-Ming Liou
Jaw-Town Lin
Wei-Jei Lee
Hsiu-Po Wang
Yi-Chia Lee
Han-Mo Chiu
Ming-Shiang Wu
Publication date
01-01-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 1/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-007-9305-x

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