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Published in: Journal of Neurology 4/2017

01-04-2017 | Original Communication

The sensorimotor network dysfunction in migraineurs without aura: a resting-state fMRI study

Authors: Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qi-Ting Zhang, Qian Yao, Haifeng Lu, Hui Zhang, Ge-Fei Li, Yi-Lan Wu, Yi-Sheng Liu, Feng-Di Liu, Mei-Ting Zhuang, Yan-Hui Shi, Tian-Yu Hou, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu, Xiaoxia Du

Published in: Journal of Neurology | Issue 4/2017

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Abstract

Migraine is a common recurrent neurological disorder combining nausea, vomiting, and hypersensitivities to visual, auditory, olfactory and somatosensory stimuli. However, the dysfunction of the sensorimotor network in migraineurs has not been well clarified. In the present study, we evaluated the dysfunction of the sensorimotor network in 30 migraineurs without aura and in 31 controls by combining regional homogeneity (ReHo), amplitudes of low-frequency fluctuation (ALFF) and degree centrality (DC) analysis methods based on resting-state fMRI. A seed-based functional connectivity (FC) analysis was used to investigate whether the dysfunctional areas within the sensorimotor network exhibited abnormal FC with other brain areas. Compared to the controls, the migraineurs without aura exhibited significantly smaller ReHo, ALFF and DC values in the primary somatosensory cortex (S1) and right premotor cortex (PMC). The migraineurs showed weaker FC between the S1 and brain areas within the pain intensity and spatial discrimination pathways and trigemino-thalamo-cortical nociceptive pathway. We proposed that the dysfunction of the S1 and PMC and the decreased FC between the S1 and brain areas in migraineurs without aura may disrupt the discrimination of sensory features of pain and affect nociception pathways, and would be involved in the dysfunctional mechanism in migraine.
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Metadata
Title
The sensorimotor network dysfunction in migraineurs without aura: a resting-state fMRI study
Authors
Jilei Zhang
Jingjing Su
Mengxing Wang
Ying Zhao
Qi-Ting Zhang
Qian Yao
Haifeng Lu
Hui Zhang
Ge-Fei Li
Yi-Lan Wu
Yi-Sheng Liu
Feng-Di Liu
Mei-Ting Zhuang
Yan-Hui Shi
Tian-Yu Hou
Rong Zhao
Yuan Qiao
Jianqi Li
Jian-Ren Liu
Xiaoxia Du
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 4/2017
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-017-8404-4

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