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Neurological Sciences
Published in: Neurological Sciences 7/2015

01-07-2015 | Review Article

The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature

Authors: Rong Li, Chen Huang, Jian Chen, Yang Guo, Sheng Tan

Published in: Neurological Sciences | Issue 7/2015

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Abstract

Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke. Some studies have found that UA is a predictor for stroke by mechanisms involved in development. There are some controversies about whether it is an independent effect of UA or an epiphenomenon. UA has been widely concerned for its neuroprotective effect as an antioxidant. In some experimental models of acute ischemic stroke, UA levels are associated with better functional recovery because of its synergistic effect with alteplase. In this review, a comprehensive literature search was conducted through Pubmed (1980–October 2014) to review the association of UA with the outcome of stroke. Finally, we outline the available clinical trial data supporting UA as a type of neuroprotective agents for the ischemic stroke.
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Metadata
Title
The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature
Authors
Rong Li
Chen Huang
Jian Chen
Yang Guo
Sheng Tan
Publication date
01-07-2015
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 7/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-015-2151-z

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