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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 11/2015

01-11-2015 | Allergens (RK Bush and JA Woodfolk, Section Editors)

The Role of the Skin Microbiome in Atopic Dermatitis

Authors: Michael R. Williams, Richard L. Gallo

Published in: Current Allergy and Asthma Reports | Issue 11/2015

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Abstract

Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the population worldwide. The incidence of AD has increased over the last several decades along with AD’s burden on the physical and psychological health of the patient and family. However, current advances in understanding the mechanisms behind the pathophysiology of AD are leading to a hopeful outlook for the future. Staphylococcus aureus (S. aureus) colonization on AD skin has been directly correlated to disease severity but the functions of other members of the skin bacterial community may be equally important. Applying knowledge gained from understanding the role of the skin microbiome in maintaining normal skin immune function, and addressing the detrimental consequences of microbial dysbiosis in driving inflammation, is a promising direction for development of new treatments. This review discusses current preclinical and clinical research focused on determining how the skin microbiome may influence the development of AD.
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Metadata
Title
The Role of the Skin Microbiome in Atopic Dermatitis
Authors
Michael R. Williams
Richard L. Gallo
Publication date
01-11-2015
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 11/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-015-0567-4

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