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01-07-2014 | SSAT/ASCRS Joint Symposium

The Role of the Pathologist in the Diagnosis and Treatment of Dysplasia in Inflammatory Bowel Disease

Authors: Mariana Berho, Daniela Allende

Published in: Journal of Gastrointestinal Surgery | Issue 7/2014

Excerpt

It has been clearly demonstrated that patients suffering from long-standing inflammatory bowel disease (IBD) (ulcerative colitis and Crohn’s disease) are at increased risk of developing colorectal cancer (CRC). The exact magnitude of this risk is difficult to measure and ranges widely according to different reports. Several reasons could explain this variability including (1) selection bias: population based vs specialized centers; (2) practice patterns, different threshold among physicians to perform colectomies; (3) widespread use of medications that have been proven to reduce the risk of colorectal cancer (5-ASA); and (4) rigorous endoscopic surveillance programs. …

Triantafillidis J, Nasioulas G, Kosmidi P.Colorectal Cancer and Inflammatory Bowel Disease: Epidemiology, Risk Factors, Mechanisms of Carcinogenesis and Prevention Strategies. Anticancer Res 2009; 29: 2727-2738PubMed

Lucas M. Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer. Dig Dis. 2010:619-624.

Thomas T, Abrams KA, Robinson RJ et al. Meta-analysis: Cancer risk of low grade dysplasia in chronic ulcerative colitis. Aliment Pharmacol Ther 2007;25:657-668.PubMedCrossRef

Odze R, Goldblum J, Noffsinger A et al. Interobserver variability in the diagnosis of ulcerative colitis-associated dysplasia by telepathology. Mod Pathol 2002;379-386

Odze R, Tomaszewski J, Feldman M et al. Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology. Oncol Rep 2006;16:1123-1129.PubMed

Title: The Role of the Pathologist in the Diagnosis and Treatment of Dysplasia in Inflammatory Bowel Disease
Authors: Mariana Berho
Daniela Allende
Publication date: 01-07-2014
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 7/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-014-2505-5

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The Role of the Pathologist in the Diagnosis and Treatment of Dysplasia in Inflammatory Bowel Disease

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