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Current Heart Failure Reports
Published in: Current Heart Failure Reports 5/2020

01-10-2020 | Translational Research in Heart Failure (J. Backs and M. van den Hoogenhof, Section Editors)

The Role of TGF—β Signaling in Cardiomyocyte Proliferation

Authors: Daniel W. Sorensen, Jop H. van Berlo

Published in: Current Heart Failure Reports | Issue 5/2020

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Abstract

Purpose of Review

The loss of contractile function after heart injury remains one of the major healthcare issues of our time. One strategy to deal with this problem would be to increase the number of cardiomyocytes to enhance cardiac function. In the last couple of years, reactivation of cardiomyocyte proliferation has repeatedly demonstrated to aid in functional recovery after cardiac injury.

Recent Findings

The Tgf-β superfamily plays key roles during development of the heart and populating the embryonic heart with cardiomyocytes. In this review, we discuss the role of Tgf-β signaling in regulating cardiomyocyte proliferation during development and in the setting of cardiac regeneration.

Summary

Although various pathways to induce cardiomyocyte proliferation have been established, the extent to which cardiomyocyte proliferation requires or involves activation of the Tgf-β superfamily is not entirely clear. More research is needed to better understand cross-talk between pathways that regulate cardiomyocyte proliferation.
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Metadata
Title
The Role of TGF—β Signaling in Cardiomyocyte Proliferation
Authors
Daniel W. Sorensen
Jop H. van Berlo
Publication date
01-10-2020
Publisher
Springer US
Published in
Current Heart Failure Reports / Issue 5/2020
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-020-00470-2

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