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Obesity Surgery
Published in: Obesity Surgery 5/2017

01-05-2017 | Original Contributions

The Role of Sleeve Gastrectomy in Reducing Cardiovascular Risk

Authors: Luciana Tromba, Francesco Tartaglia, Sabino Carbotta, Nadia Sforza, Fabio Pelle, Vanessa Colagiovanni, Giovanni Carbotta, Stefania Cavaiola, Giovanni Casella

Published in: Obesity Surgery | Issue 5/2017

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Abstract

Background

Obesity is an independent cardiovascular risk factor and a catalyst of other cardiovascular risk factors, such as hypertension, dyslipidemia, type 2 diabetes mellitus (DM2) and metabolic syndrome.

Methods

We analyzed cardiovascular risk in obese patients before and after sleeve gastrectomy (SG). To this end, we studied changes in body mass index (BMI), blood chemistry parameters that characterize the risk of atherosclerosis and instrumental parameters (objective markers of this risk), namely intima-media thickness (IMT) and flow-mediated dilation (FMD), the latter reflecting endothelial function. We also considered purely cardiac parameters—mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE)—which describe cardiac risk more specifically than the ejection fraction. Alteration of one or more of these parameters determines an increase in cardiovascular morbidity and mortality.

Results

The results showed that weight loss, in patients undergoing SG, is accompanied by a reduced BMI and a marked improvement in blood chemistry, confirming what has already been shown in many other studies, but the most interesting finding was the effect of SG on the instrumental markers of atherosclerosis. In particular, carotid IMT was significantly reduced (p < 0.001) and FMD significantly improved. MAPSE and TAPSE also improved significantly at both follow-up assessments (p < 0.001).

Conclusions

This study suggests that SG should be considered from a broader perspective, i.e. as a weight loss treatment that also improves obesity-related morbidity and mortality, benefitting both the patient and, in an economic sense, the society as a whole.
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Metadata
Title
The Role of Sleeve Gastrectomy in Reducing Cardiovascular Risk
Authors
Luciana Tromba
Francesco Tartaglia
Sabino Carbotta
Nadia Sforza
Fabio Pelle
Vanessa Colagiovanni
Giovanni Carbotta
Stefania Cavaiola
Giovanni Casella
Publication date
01-05-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 5/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2441-4

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