Skip to main content
Top
Published in: International Ophthalmology 1/2021

01-01-2021 | Original Paper

The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients

Authors: Dilek Uzlu, Hidayet Erdöl, Ahmet Mehmet Somuncu, Ahmet Duhan Özbay, Mehmet Kola, Büşra Köse

Published in: International Ophthalmology | Issue 1/2021

Login to get access

Abstract

Aim

To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in idiopathic epiretinal membrane (IERM) patients, and their relations with visual acuity.

Method

Fifty-seven IERM and 51 control patients were included. All patients underwent comprehensive ophthalmological examination and complete blood count tests, and NLR and PLR values were calculated. Patients with IERM were compared with the control group, and associations with visual prognosis were evaluated. These ratios’ cut-off values for IERM were also calculated

Results

NLR values were statistically significantly higher in the IERM group than in the control group (p = 0.001). No significant difference was observed between the IERM and control groups in terms of PLR (p = 0.43). No significant correlation was determined between visual acuity and NLR or PLR (r = 0.05, p = 0.66; and r = 0.18, p = 0.16, respectively). The cut-off value for NLR was 1.91.

Conclusion

Patients with IERM showed significantly increased NLR compared to control subjects suggesting that IERM patients may be prone to have high NLR values.
Literature
1.
go back to reference Hillenkamp J, Saikia P, Herrmann WA et al (2007) Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial. Graefes Arch Clin Exp Ophthalmol 245(7):97979CrossRef Hillenkamp J, Saikia P, Herrmann WA et al (2007) Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial. Graefes Arch Clin Exp Ophthalmol 245(7):97979CrossRef
2.
go back to reference Bu SC, Kuijer R, Li XR et al (2014) Idiopathıc epiretinal membrane. Retina 34(12):2317–2335CrossRef Bu SC, Kuijer R, Li XR et al (2014) Idiopathıc epiretinal membrane. Retina 34(12):2317–2335CrossRef
3.
go back to reference Pearlstone AD (1985) The incidence of idiopathic preretinal macular gliosis. Ann Ophthalmol 17(6):378–380PubMed Pearlstone AD (1985) The incidence of idiopathic preretinal macular gliosis. Ann Ophthalmol 17(6):378–380PubMed
4.
go back to reference Hiscott PS, Grierson I, McLeod D (1985) Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol 69(11):810–823CrossRef Hiscott PS, Grierson I, McLeod D (1985) Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol 69(11):810–823CrossRef
5.
go back to reference Joshi M, Agrawal S, Christoforidis JB (2013) Inflamatory mechanisms of idiopathic epiretinal membrane formation. Mediat Inflamm 2013:192582CrossRef Joshi M, Agrawal S, Christoforidis JB (2013) Inflamatory mechanisms of idiopathic epiretinal membrane formation. Mediat Inflamm 2013:192582CrossRef
6.
go back to reference Kose N, Akın F, Yıldırım T et al (2019) The association between the lymphocyte to monocyte ratio and coronary artery disease severity in patients with stable coronary arter disease. Eur Rev Med Pharmacol Sci 23:2570–2575PubMed Kose N, Akın F, Yıldırım T et al (2019) The association between the lymphocyte to monocyte ratio and coronary artery disease severity in patients with stable coronary arter disease. Eur Rev Med Pharmacol Sci 23:2570–2575PubMed
7.
go back to reference Song X, Chen D, Yuan M et al (2018) Total lymphocyte count, neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in advanced non-small cell lung cancer with chemoradiotherapy. Cancer Manag Res 5(10):6677–6683CrossRef Song X, Chen D, Yuan M et al (2018) Total lymphocyte count, neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in advanced non-small cell lung cancer with chemoradiotherapy. Cancer Manag Res 5(10):6677–6683CrossRef
8.
go back to reference Lee YH, Song GG (2018) Neutrophil-to-lymphocyte ratio, mean platelet volume and platelet-to-lymphocyte ratio in Behçet’s disease and their correlation with disease activity: a meta-analysis. Int J Rheum Dis 21(12):2180–2187CrossRef Lee YH, Song GG (2018) Neutrophil-to-lymphocyte ratio, mean platelet volume and platelet-to-lymphocyte ratio in Behçet’s disease and their correlation with disease activity: a meta-analysis. Int J Rheum Dis 21(12):2180–2187CrossRef
9.
go back to reference Vakili H, Shirazi M, Charkhkar M et al (2017) Correlation of platelet-to-lymphocyte ratio and neutrophil-to-lymphocycte ratio with thrombolysis in myocardial infarction frame count in ST-segment elevation myocardial infarction. Eur J Clin Investig 47(4):322–327CrossRef Vakili H, Shirazi M, Charkhkar M et al (2017) Correlation of platelet-to-lymphocyte ratio and neutrophil-to-lymphocycte ratio with thrombolysis in myocardial infarction frame count in ST-segment elevation myocardial infarction. Eur J Clin Investig 47(4):322–327CrossRef
10.
go back to reference Wang Q, Ma J, Jiang Z et al (2018) Prognostic value of neutrophil-to-lymphocycte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: a systematic review and meta-analysis. Int Angiol 37(1):4–11 Wang Q, Ma J, Jiang Z et al (2018) Prognostic value of neutrophil-to-lymphocycte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: a systematic review and meta-analysis. Int Angiol 37(1):4–11
11.
go back to reference Ozgonul C, Sertoğlu E, Mumcuooglu T et al (2016) Neutrophil to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel biomarkers of primary open-angle glaucoma. J Glaucoma 25(10):e815–e820CrossRef Ozgonul C, Sertoğlu E, Mumcuooglu T et al (2016) Neutrophil to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel biomarkers of primary open-angle glaucoma. J Glaucoma 25(10):e815–e820CrossRef
12.
go back to reference Karaca EE, Ozmen MC, Ekici F et al (2014) Neutrophil-to-lymphocyte ratio may predict progression in patients with keratoconus. Cornea 33:1168–1173CrossRef Karaca EE, Ozmen MC, Ekici F et al (2014) Neutrophil-to-lymphocyte ratio may predict progression in patients with keratoconus. Cornea 33:1168–1173CrossRef
13.
go back to reference Ilhan N, Daglioglu MC, Ilhan O et al (2015) Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration. Ocul Immunol Inflamm 23(4):287–290CrossRef Ilhan N, Daglioglu MC, Ilhan O et al (2015) Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration. Ocul Immunol Inflamm 23(4):287–290CrossRef
14.
go back to reference Dursun A, Ozturk S, Yucel H et al (2015) Association of neutrophil/lymphocyte ratio and retinal vein occlusion. Eur J Ophthalmmol 25(4):343–346CrossRef Dursun A, Ozturk S, Yucel H et al (2015) Association of neutrophil/lymphocyte ratio and retinal vein occlusion. Eur J Ophthalmmol 25(4):343–346CrossRef
15.
go back to reference Mandelcorn E, Khan Y, Javorska L et al (2003) Idiopathic epiretinal membranes: cell type, growth factor expression, and fluorescein angiographic and retinal photographic correlations. Can J Ophthalmol 38:457–463CrossRef Mandelcorn E, Khan Y, Javorska L et al (2003) Idiopathic epiretinal membranes: cell type, growth factor expression, and fluorescein angiographic and retinal photographic correlations. Can J Ophthalmol 38:457–463CrossRef
16.
go back to reference Minchiotti S, Stampachiacchiere B, Micera A et al (2008) Human idiopathic epiretinal membranes express NGF and NGF receptors. Retina 28:628–637CrossRef Minchiotti S, Stampachiacchiere B, Micera A et al (2008) Human idiopathic epiretinal membranes express NGF and NGF receptors. Retina 28:628–637CrossRef
17.
go back to reference Bu SC, Kuijer R, van der Worp RJ et al (2015) Immunohistochemical evaluation of idiopathic epiretinal membranes and in vitro studies on the effect of TGF-b on Muller cells. Investig Ophthalmol Vis Sci 56:6506–6514CrossRef Bu SC, Kuijer R, van der Worp RJ et al (2015) Immunohistochemical evaluation of idiopathic epiretinal membranes and in vitro studies on the effect of TGF-b on Muller cells. Investig Ophthalmol Vis Sci 56:6506–6514CrossRef
18.
go back to reference Kanda A, Noda K, Hirose I et al (2019) TGF-B-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane. Sci Rep 9:673CrossRef Kanda A, Noda K, Hirose I et al (2019) TGF-B-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane. Sci Rep 9:673CrossRef
19.
go back to reference Iannetti L, Accorinti M, Malagola R et al (2011) Role of the intravitreal growth factors in the pathogenesis of idiopathic epiretinal membrane. Investig Ophthalmol Vis Sci 52:5786–5789CrossRef Iannetti L, Accorinti M, Malagola R et al (2011) Role of the intravitreal growth factors in the pathogenesis of idiopathic epiretinal membrane. Investig Ophthalmol Vis Sci 52:5786–5789CrossRef
20.
go back to reference Dikkaya F, Erdur SK, Ozsutcu M et al (2018) The significance of neutrophil-to-lymphocycte ratio in idiopathic epiretinal membrane. Int Ophthalmol 38:1393–1397CrossRef Dikkaya F, Erdur SK, Ozsutcu M et al (2018) The significance of neutrophil-to-lymphocycte ratio in idiopathic epiretinal membrane. Int Ophthalmol 38:1393–1397CrossRef
Metadata
Title
The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients
Authors
Dilek Uzlu
Hidayet Erdöl
Ahmet Mehmet Somuncu
Ahmet Duhan Özbay
Mehmet Kola
Büşra Köse
Publication date
01-01-2021
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2021
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01557-4

Other articles of this Issue 1/2021

International Ophthalmology 1/2021 Go to the issue