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Molecular Pain
Published in: Molecular Pain 1/2015

Open Access 01-12-2015 | Research

The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia

Authors: Ana Paula Luiz, Olga Kopach, Sonia Santana-Varela, John N. Wood

Published in: Molecular Pain | Issue 1/2015

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Abstract

Background

Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). We examined the role of the voltage-gated sodium channel subtype Nav1.9 in the development of trigeminal neuralgia.

Results

We found that Nav1.9 is required for the development of both thermal and mechanical hypersensitivity induced by constriction of the infraorbital nerve (CION). The CION model does not induce change on Nav1.9 mRNA expression in the ipsilateral TG neurons when evaluated 9 days after surgery.

Conclusions

These results demonstrate that Nav1.9 channels play a critical role in the development of orofacial neuropathic pain. New routes for the treatment of orofacial neuropathic pain focussing on regulation of the voltage-gated Nav1.9 sodium channel activity should be investigated.
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Metadata
Title
The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia
Authors
Ana Paula Luiz
Olga Kopach
Sonia Santana-Varela
John N. Wood
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2015
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/s12990-015-0076-4

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