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01-11-2015 | Topic Review

The role of ion channels in malignant brain tumors

Authors: Ole J. Simon, Thomas Müntefering, Oliver M. Grauer, Sven G. Meuth

Published in: Journal of Neuro-Oncology | Issue 2/2015

Abstract

Malignant gliomas are the most common primary brain tumors and have poor clinical prognosis, despite multimodal therapeutic strategies. In recent years, ion channels have emerged as major players in tumor pathophysiology regarding all hallmarks of cancer. Since ion channels are easily accessible structures, they may prove to be effective targets for canner therapy, although their broad expression pattern and role in physiological processes should be taken into consideration. This review summarizes the current knowledge on the role of ion channels in the pathophysiology of malignant gliomas, especially glioblastoma, and evaluates their potential role in targeted antiglioma therapy.

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Title: The role of ion channels in malignant brain tumors
Authors: Ole J. Simon
Thomas Müntefering
Oliver M. Grauer
Sven G. Meuth
Publication date: 01-11-2015
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2015
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1896-9

At a glance: The STEP trials

Springer Medicine

The role of ion channels in malignant brain tumors

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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