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AIDS and Behavior
Published in: AIDS and Behavior 1/2009

01-02-2009 | Original Paper

The Role of Host Genetics in the Susceptibility for HIV-associated Neurocognitive Disorders

Authors: Andrew J. Levine, Elyse J. Singer, Paul Shapshak

Published in: AIDS and Behavior | Issue 1/2009

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Abstract

Despite progress in the treatment of the Human Immunodeficiency virus (HIV), there continues to be a high prevalence of infected individuals who develop neurocognitive deficits and disorders. Our understanding of the potential cause of HIV-associated neurocognitive disorders (HAND) continues to develop on many fronts. Among them is the study of host genetics. Here, we review the most current information regarding the association between host genetics and risk for HIV infection, AIDS, and HAND. We focus on the role of dopamine dysfunction in the etiology of HAND, and propose a number of genetic polymorphisms within genes related to dopaminergic functioning and other neurobiological factors that may confer vulnerability or protection against HAND.
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Metadata
Title
The Role of Host Genetics in the Susceptibility for HIV-associated Neurocognitive Disorders
Authors
Andrew J. Levine
Elyse J. Singer
Paul Shapshak
Publication date
01-02-2009
Publisher
Springer US
Published in
AIDS and Behavior / Issue 1/2009
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-008-9360-x

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