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Open Access 01-12-2017 | Review

The role of exosomes in the pathogenesis of Alzheimer’ disease

Authors: Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu, Lu Shen

Published in: Translational Neurodegeneration | Issue 1/2017

Abstract

Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on nerve development, activation and regeneration. In addition, exosomes have been observed to be involved in spreading pathological misfolded proteins, thereby leading to the onset and propagation of disease. Alzheimer disease (AD) is the most common form of dementia and characterized by two types of lesions: amyloid plaques and neurofibrillary tangles. Accumulating evidence has demonstrated that exosomes are associated with amyloid precursor (APP) and Tau proteins and play a controversial role in Alzheimer’s disease process. In this review, we will discuss the role of exosomes in the metabolism and secretion of APP and Tau proteins and their subsequent impact on AD pathogenesis.

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Title: The role of exosomes in the pathogenesis of Alzheimer’ disease
Authors: Tingting Xiao
Weiwei Zhang
Bin Jiao
Chu-Zheng Pan
Xixi Liu
Lu Shen
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Translational Neurodegeneration / Issue 1/2017
Electronic ISSN: 2047-9158
DOI: https://doi.org/10.1186/s40035-017-0072-x

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The role of exosomes in the pathogenesis of Alzheimer’ disease

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