Skip to main content
Top
Published in: Netherlands Heart Journal 11/2013

Open Access 01-11-2013 | Original Article – E-Learning

The role of exercise echocardiography in the management of mitral valve disease

Authors: R. Jansen, P. A. M. Kracht, M. J. Cramer, W. J. Tietge, L. A. van Herwerden, R. J. M. Klautz, J. Kluin, S. A. J. Chamuleau

Published in: Netherlands Heart Journal | Issue 11/2013

Login to get access

Abstract

Purpose

Exercise echocardiography can assess the dynamic component of mitral valve (MV) disease and may therefore be helpful for the clinical decision-making by the heart team. The purpose of this study is to determine the role of exercise echocardiography in the management of disproportionately symptomatic or otherwise atypical patients with mitral regurgitation (MR) and stenosis (MS) in clinical practice.

Methods

Data of 14 MR and 14 MS patients, including echocardiograms at rest, were presented retrospectively to an experienced heart team to determine treatment strategy. Subsequently, exercise echo data were provided whereupon once again the treatment strategy was determined. This resulted in: value of exercise echo by means of 1) alteration or 2) confirmation of treatment strategy or 3) no additional value.

Results

During exercise the echocardiographic severity of MV disease increased in 9 (64 %) MR and 8 (57 %) MS patients. Based upon alteration or confirmation of the treatment strategy, the value of exercise echocardiography in the management of MR and MS was 86 % and 57 %, respectively.

Conclusion

This study showed that physical exercise echo can have an important role in the clinical decision-making of challenging patients with MV disease. Exercise echocardiography had additional value to the treatment strategy in 71 % of these patients.
Literature
1.
go back to reference Lancellotti P, Magne J. Stress testing for the evaluation of patients with mitral regurgitation. Curr Opin Cardiol. 2012;27:492–8.PubMedCrossRef Lancellotti P, Magne J. Stress testing for the evaluation of patients with mitral regurgitation. Curr Opin Cardiol. 2012;27:492–8.PubMedCrossRef
2.
go back to reference Kamp O, Cramer MJM. History of echocardiography in the Netherlands: 30 years of education and clinical applications. Neth Heart J. 2008;16:16–20.PubMedCrossRef Kamp O, Cramer MJM. History of echocardiography in the Netherlands: 30 years of education and clinical applications. Neth Heart J. 2008;16:16–20.PubMedCrossRef
3.
go back to reference Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42:S1–S44.PubMedCrossRef Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42:S1–S44.PubMedCrossRef
4.
go back to reference Bonow RO, Carabello BA, Chatterjee K, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing committee to revise the 1998 guidelines for the management of patients with Valvular Heart Disease). Circulation. 2006;114:e84–e231.PubMedCrossRef Bonow RO, Carabello BA, Chatterjee K, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing committee to revise the 1998 guidelines for the management of patients with Valvular Heart Disease). Circulation. 2006;114:e84–e231.PubMedCrossRef
5.
go back to reference Joziasse IC, Vink A, Cramer MJ, et al. Biscupid stenotic aortic valves: clinical characteristics and morphological assessment using MRI and echocardiography. Neth Heart J. 2011;19:119–25.PubMedCrossRef Joziasse IC, Vink A, Cramer MJ, et al. Biscupid stenotic aortic valves: clinical characteristics and morphological assessment using MRI and echocardiography. Neth Heart J. 2011;19:119–25.PubMedCrossRef
7.
go back to reference Heinle SK, Tice FD, Kisslo J. Effect of dobutamine stress echocardiography on mitral regurgitation. J Am Coll Cardiol. 1995;25:122–7.PubMedCrossRef Heinle SK, Tice FD, Kisslo J. Effect of dobutamine stress echocardiography on mitral regurgitation. J Am Coll Cardiol. 1995;25:122–7.PubMedCrossRef
8.
go back to reference Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003;24:1231–43.PubMedCrossRef Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003;24:1231–43.PubMedCrossRef
9.
go back to reference Tietge WJ, de Heer LM, van Hessen MW, et al. Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. Neth Heart J. 2012;20:94–101.PubMedCrossRef Tietge WJ, de Heer LM, van Hessen MW, et al. Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. Neth Heart J. 2012;20:94–101.PubMedCrossRef
10.
go back to reference Horstkotte D, Niehues R, Strauer BE. Pathomorphological aspects, aetiology and natural history of acquired mitral valve stenosis. Eur Heart J. 1991;12(Suppl B):55.PubMedCrossRef Horstkotte D, Niehues R, Strauer BE. Pathomorphological aspects, aetiology and natural history of acquired mitral valve stenosis. Eur Heart J. 1991;12(Suppl B):55.PubMedCrossRef
11.
go back to reference Picano E, Pibarot P, Lancellotti P, et al. The emerging role of exercise testing and stress echocardiography in valvular heart disease. J Am Coll Cardiol. 2009;54:2251–60.PubMedCrossRef Picano E, Pibarot P, Lancellotti P, et al. The emerging role of exercise testing and stress echocardiography in valvular heart disease. J Am Coll Cardiol. 2009;54:2251–60.PubMedCrossRef
12.
go back to reference Picard MH, Adams D, Bierig SM, et al. American Society of Echocardiography recommendations for quality echocardiography laboratory operations. J Am Soc Echocardiogr. 2011;24:1–10.PubMedCrossRef Picard MH, Adams D, Bierig SM, et al. American Society of Echocardiography recommendations for quality echocardiography laboratory operations. J Am Soc Echocardiogr. 2011;24:1–10.PubMedCrossRef
13.
go back to reference Van de Heyning CM, Magne J, Lancellotti P, et al. The importance of exercise echocardiography for clinical decision making in primary mitral regurgitation. J Cardiovasc Med. 2012;13:260–5.CrossRef Van de Heyning CM, Magne J, Lancellotti P, et al. The importance of exercise echocardiography for clinical decision making in primary mitral regurgitation. J Cardiovasc Med. 2012;13:260–5.CrossRef
14.
go back to reference Lancellotti P, Gérard P, Piérard L. Long term outcome of patients with heart failure and dynamic functional mitral regurgitation. Eur Heart J. 2005;26:1528–32.PubMedCrossRef Lancellotti P, Gérard P, Piérard L. Long term outcome of patients with heart failure and dynamic functional mitral regurgitation. Eur Heart J. 2005;26:1528–32.PubMedCrossRef
15.
go back to reference Tischler MD, Battle RW, Saha M, et al. Observations suggesting a high incidence of exercise-induced severe mitral regurgitation in patients with mild rheumatic mitral valve disease at rest. J Am Coll Cardiol. 1995;25:128–33.PubMedCrossRef Tischler MD, Battle RW, Saha M, et al. Observations suggesting a high incidence of exercise-induced severe mitral regurgitation in patients with mild rheumatic mitral valve disease at rest. J Am Coll Cardiol. 1995;25:128–33.PubMedCrossRef
16.
go back to reference Voelker W, Jaksch R, Dittman H, et al. Validation of continuous-wave Doppler measurements of mitral valve gradients during exercise—A simultaneous Doppler-catheter study. Eur Heart J. 1989;10:737–46.PubMed Voelker W, Jaksch R, Dittman H, et al. Validation of continuous-wave Doppler measurements of mitral valve gradients during exercise—A simultaneous Doppler-catheter study. Eur Heart J. 1989;10:737–46.PubMed
17.
go back to reference Sagar KB, Wann SL, Paulson WJ, et al. Role of exercise Doppler echocardiography in isolated mitral stenosis. Chest. 1987;92:27–30.PubMedCrossRef Sagar KB, Wann SL, Paulson WJ, et al. Role of exercise Doppler echocardiography in isolated mitral stenosis. Chest. 1987;92:27–30.PubMedCrossRef
18.
go back to reference Braverman AC, Thomas JD, Lee RT. Doppler echocardiographic estimation of mitral valve area during changing hemodynamic conditions. Am J Cardiol. 1991;68:1485–90.PubMedCrossRef Braverman AC, Thomas JD, Lee RT. Doppler echocardiographic estimation of mitral valve area during changing hemodynamic conditions. Am J Cardiol. 1991;68:1485–90.PubMedCrossRef
19.
go back to reference Leavitt JI, Coats MH, Falk RH. Effects of exercise on transmitral gradient and pulmonary artery pressure in patients with mitral stenosis or a prosthetic mitral valve: a Doppler echocardiographic study. J Am Coll Cardiol. 1991;17:1520–6.PubMedCrossRef Leavitt JI, Coats MH, Falk RH. Effects of exercise on transmitral gradient and pulmonary artery pressure in patients with mitral stenosis or a prosthetic mitral valve: a Doppler echocardiographic study. J Am Coll Cardiol. 1991;17:1520–6.PubMedCrossRef
20.
go back to reference Voelker W, Berner A, Regele B, et al. Effect of exercise on valvular resistance in patients with mitral stenosis. J Am Coll Cardiol. 1993;22:777–82.PubMedCrossRef Voelker W, Berner A, Regele B, et al. Effect of exercise on valvular resistance in patients with mitral stenosis. J Am Coll Cardiol. 1993;22:777–82.PubMedCrossRef
21.
go back to reference Tunick PA, Freedberg RS, Gargiulo A, et al. Exercise Doppler echocardiography as an aid to clinical decision making in mitral valve disease. J Am Soc Echocardiogr. 1992;5:225–30.PubMed Tunick PA, Freedberg RS, Gargiulo A, et al. Exercise Doppler echocardiography as an aid to clinical decision making in mitral valve disease. J Am Soc Echocardiogr. 1992;5:225–30.PubMed
22.
go back to reference Hecker S, Zabalgoitia M, Ashline P, et al. Comparison of exercise and dobutamine stress echocardiography in assessing mitral stenosis. Am J Cardiol. 1997;80:1374–7.PubMedCrossRef Hecker S, Zabalgoitia M, Ashline P, et al. Comparison of exercise and dobutamine stress echocardiography in assessing mitral stenosis. Am J Cardiol. 1997;80:1374–7.PubMedCrossRef
23.
go back to reference Song JK, Kang DH, Lee CW, et al. Factors determining the exercise capacity in mitral stenosis. Am J Cardiol. 1996;78:1060–2.PubMedCrossRef Song JK, Kang DH, Lee CW, et al. Factors determining the exercise capacity in mitral stenosis. Am J Cardiol. 1996;78:1060–2.PubMedCrossRef
24.
25.
go back to reference Kasalicky J, Hurych J, Widimsky J, et al. Left heart haemodynamics at rest and during exercise in patients with mitral stenosis. Br Heart J. 1968;30:188–95.PubMedCrossRef Kasalicky J, Hurych J, Widimsky J, et al. Left heart haemodynamics at rest and during exercise in patients with mitral stenosis. Br Heart J. 1968;30:188–95.PubMedCrossRef
26.
go back to reference Cheriex EC, Pieters FA, Janssen JH, et al. Value of exercise Doppler-echocardiography in patients with mitral stenosis. Int J Cardiol. 1994;45:219–26.PubMedCrossRef Cheriex EC, Pieters FA, Janssen JH, et al. Value of exercise Doppler-echocardiography in patients with mitral stenosis. Int J Cardiol. 1994;45:219–26.PubMedCrossRef
27.
go back to reference Abramson SV, Burke JF, Kelly Jr JJ, et al. Pulmonary hypertension predicts mortality and morbidity in patients with dilated cardiomyopathy. Ann Intern Med. 1992;116:888–95.PubMedCrossRef Abramson SV, Burke JF, Kelly Jr JJ, et al. Pulmonary hypertension predicts mortality and morbidity in patients with dilated cardiomyopathy. Ann Intern Med. 1992;116:888–95.PubMedCrossRef
28.
go back to reference Lebrun F, Lancellotti P, Pierard LA. Quantitation of functional mitral regurgitation during bicycle exercise in patients with heart failure. JACC. 2001;38:1685–92. Lebrun F, Lancellotti P, Pierard LA. Quantitation of functional mitral regurgitation during bicycle exercise in patients with heart failure. JACC. 2001;38:1685–92.
29.
go back to reference Bossone E, Rubenfire M, Bach DS, et al. Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: implications for the diagnosis of pulmonary hypertension. J Am Coll Cardiol. 1999;33:1662–6.PubMedCrossRef Bossone E, Rubenfire M, Bach DS, et al. Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: implications for the diagnosis of pulmonary hypertension. J Am Coll Cardiol. 1999;33:1662–6.PubMedCrossRef
30.
go back to reference Janosi A, Apor P, Hankoczy J, et al. Pulmonary artery pressure and oxygen consumption measurement during supine bicycle exercise. Chest. 1988;93:419–21.PubMedCrossRef Janosi A, Apor P, Hankoczy J, et al. Pulmonary artery pressure and oxygen consumption measurement during supine bicycle exercise. Chest. 1988;93:419–21.PubMedCrossRef
31.
go back to reference Argiento P, Chesler N, Mule M, et al. Exercise stress echocardiography for the study of the pulmonary circulation. Eur Respir J. 2010;35:1273–8.PubMedCrossRef Argiento P, Chesler N, Mule M, et al. Exercise stress echocardiography for the study of the pulmonary circulation. Eur Respir J. 2010;35:1273–8.PubMedCrossRef
32.
go back to reference La Gerche A, Heidbüchel H, Burns AT, et al. Disproportionate exercise load and remodeling of the athlete’s right ventricle. Med Sci Sports Exerc. 2011;43:974–81.PubMedCrossRef La Gerche A, Heidbüchel H, Burns AT, et al. Disproportionate exercise load and remodeling of the athlete’s right ventricle. Med Sci Sports Exerc. 2011;43:974–81.PubMedCrossRef
33.
go back to reference Mahjoub H, Levy F, Cassol M, et al. Effects of age on pulmonary artery systolic pressure at rest and during exercise in normal adults. Eur J Echocardiogr. 2009;10:635–40.PubMedCrossRef Mahjoub H, Levy F, Cassol M, et al. Effects of age on pulmonary artery systolic pressure at rest and during exercise in normal adults. Eur J Echocardiogr. 2009;10:635–40.PubMedCrossRef
34.
go back to reference Leung KY, van Stralen M, Danilouchkine MG, et al. Automated analysis of three-dimensional stress echocardiography. Neth Heart J. 2011;19:307–10.PubMedCrossRef Leung KY, van Stralen M, Danilouchkine MG, et al. Automated analysis of three-dimensional stress echocardiography. Neth Heart J. 2011;19:307–10.PubMedCrossRef
Metadata
Title
The role of exercise echocardiography in the management of mitral valve disease
Authors
R. Jansen
P. A. M. Kracht
M. J. Cramer
W. J. Tietge
L. A. van Herwerden
R. J. M. Klautz
J. Kluin
S. A. J. Chamuleau
Publication date
01-11-2013
Publisher
Bohn Stafleu van Loghum
Published in
Netherlands Heart Journal / Issue 11/2013
Print ISSN: 1568-5888
Electronic ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-013-0452-5

Other articles of this Issue 11/2013

Netherlands Heart Journal 11/2013 Go to the issue