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Current Nutrition Reports
Published in: Current Nutrition Reports 1/2013

01-03-2013 | Cancer (MF Leitzmann, Section Editor)

The Role of Diabetes and Diabetes Treatments in Colorectal Cancer Mortality, Incidence, and Survival

Author: Peter T. Campbell

Published in: Current Nutrition Reports | Issue 1/2013

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Abstract

Type 2 diabetes mellitus (T2DM) and colorectal cancer are major causes of morbidity and mortality worldwide. T2DM and colorectal cancer share common risk factors related to westernized lifestyles, including high body mass index and central adiposity, low physical activity, cigarette smoking, and diets characterized by low intake of fruit and vegetables and high intake of red and processed meats and refined grains and sugars. Epidemiologic studies show that T2DM is quite convincingly associated with higher risk of colorectal cancer incidence and mortality, even after accounting for their shared risk factors. Whether T2DM is related to poorer prognosis after colorectal cancer diagnosis is less understood and controversial, although some larger studies suggest poorer prognosis among patients with T2DM. The impact of diabetes treatments, such as metformin or insulin, on colorectal cancer risk also is characterized poorly. This review describes studies on the association of diabetes and its treatments with colorectal cancer mortality, incidence, and survival. Potential clinical and biological explanations for these associations are explored.
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Metadata
Title
The Role of Diabetes and Diabetes Treatments in Colorectal Cancer Mortality, Incidence, and Survival
Author
Peter T. Campbell
Publication date
01-03-2013
Publisher
Current Science Inc.
Published in
Current Nutrition Reports / Issue 1/2013
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-012-0034-y

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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