Top

Published in:

01-02-2016

The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults

Authors: Lucette A. Cysique, Nadene Dermody, Andrew Carr, Bruce J. Brew, Maree Teesson

Published in: Journal of NeuroVirology | Issue 1/2016

Abstract

Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment completed a psychiatric interview, a depression scale, a neuropsychological, daily living, and cognitive complaints assessments at baseline and 18 months. Participants were screened for current (within 12 months of study entry) alcohol and/or substance use disorder. History of alcohol and/or substance abuse disorder prior to the 12 months entry screen and MDD treatments were recorded. Participants were grouped into two psychiatric nomenclatures: (1) lifetime: no MD episode (MDE), single MDE life-event treated and fully remitted, chronic MDD treated and stable, chronic MDD treated and unstable, and baseline untreated MDE; (2) recent: last 2 years MDE (yes or no). We found that lifetime and recent psychiatric history were more strongly associated with decreased in independence in daily living and cognitive complaints than with baseline neuropsychological performance. However, lack of full remission, instability on treatment in chronic MDD, and severity of symptoms in current MDE were factors in whether MDD impacted baseline neuropsychological performance. Depressive symptoms improved at follow-up in those with baseline moderate-severe symptoms, and MDD was not associated with neurocognitive change at 18 months. A history of alcohol and/or substance abuse disorder was significantly more frequent in those with treated and unstable chronic MDD but it was not associated with neuropsychological performance. MDD recurrence, chronicity profiles, and associated comorbidities are keys factors to understand any potential impact on neurocognitive abilities in HIV infection. More comprehensive consideration of these complex effects could serve at constructively updating the HAND diagnostic criteria.

Available only for authorised users

Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799PubMedPubMedCentralCrossRef

Atkinson JH, Heaton RK, Patterson TL, Wolfson T, Deutsch R, Brown SJ, Summers J, Sciolla A, Gutierrez R, Ellis RJ, Abramson I, Hesselink JR, McCutchan JA, Grant I (2008) Two-year prospective study of major depressive disorder in HIV-infected men. J Affect Disord 108:225–234PubMedPubMedCentralCrossRef

Australian Bureau of Statistics (2007) National survey of mental health and wellbeing: summary of results, 2007. http://www.abs.gov.au/ausstats/abs@.nsf/mf/4326.0. Accessed July 2014. ABS, (ed). ABS Cat. No. 4326.0.: Canberra: ABS, 2007

Beck AT, Steer RA, Ball R, Ranieri W (1996a) Comparison of beck depression inventories -IA and -II in psychiatric outpatients. J Pers Assess 67:588–597PubMedCrossRef

Beck AT, Steer RA, Brown GK (1996b) Manual for the beck depression inventory-II. Psychological Corporation, San Antonio

Carter SL, Rourke SB, Murji S, Shore D, Rourke BP (2003) Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: a structural equation model analysis. Neuropsychology 17:410–419PubMedCrossRef

Chelune G, Heaton R, Lehman R (1986) Neuropsychological and personality correlates of patient’s complaints of disability. In: Tarter R, Goldstein G (eds) Advances in clinical neuropsychology. Plenum Press, New York, pp 95–126CrossRef

Ciesla JA, Roberts JE (2001) Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry 158:725–730PubMedCrossRef

Cysique LA, Deutsch R, Atkinson JH, Young C, Marcotte TD, Dawson L, Grant I, Heaton RK (2007) Incident major depression does not affect neuropsychological functioning in HIV-infected men. J Int Neuropsychol Soc 13:1–11PubMedCrossRef

Cysique LA, Franklin D Jr, Abramson I, Ellis RJ, Letendre S, Collier A, Clifford D, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I, Heaton RK (2011) Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change. J Clin Exp Neuropsychol 33:505–522PubMedPubMedCentralCrossRef

Cysique LA, Bain MP, Lane TA, Brew BJ (2012) Management issues in HIV-associated neurocognitive disorders. Neurobehav HIV Med 4:63–73CrossRef

Cysique LA, Heaton RK, Kamminga J, Lane T, Gates TM, Moore DM, Hubner E, Carr A, Brew BJ (2014) HIV-associated neurocognitive disorder in Australia: a case of a high-functioning and optimally treated cohort and implications for international neuroHIV research. J Neurovirol 20:258–268PubMedPubMedCentralCrossRef

Daughters SB, Braun AR, Sargeant MN, Reynolds EK, Hopko DR, Blanco C, Lejuez CW (2008) Effectiveness of a brief behavioral treatment for inner-city illicit drug users with elevated depressive symptoms: the life enhancement treatment for substance use (LETS Act!). J Clin Psychiatry 69:122–129PubMedCrossRef

Dermody N, Batchelor J, Heaton RK, Cysique LA (2014). Cross-cultural validity of U.S. longitudinal normative standards in Australians: preliminary results. In: College of Clinical Neuropsychologists (APS), Adelaide, Australia

Fellows RP, Byrd DA, Morgello S (2013) Major depressive disorder, cognitive symptoms, and neuropsychological performance among ethnically diverse HIV+ men and women. J Int Neuropsychol Soc 19:216–225PubMedPubMedCentralCrossRef

Gibbie T, Mijch A, Ellen S, Hoy J, Hutchison C, Wright E, Chua P, Judd F (2006) Depression and neurocognitive performance in individuals with HIV/AIDS: 2-year follow-up. HIV Med 7:112–121PubMedCrossRef

Gold JA, Grill M, Peterson J, Pilcher C, Lee E, Hecht FM, Fuchs D, Yiannoutsos CT, Price RW, Robertson K, Spudich S (2014). Longitudinal characterization of depression and mood states beginning in primary HIV infection. AIDS Behav . 18(6):1124–1132

Grant I, Heaton RK (2014) Neurocognitive change in the era of combination antoretroviral therapy: a longitudinal CHARTER study. In: AIDS 2014. Melbourne, Australia

Grant I, Franklin DJ, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, CLifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, HGamst A, Fennema-Notstine C, Smith DM, Heaton RK, Group C (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 10: 2055–2062

Gudayol-Ferre E, Guardia-Olmos J, Pero-Cebollero M, Herrera-Guzman I, Camarena B, Cortes-Penagos C, Herrera-Abarca JE, Martinez-Medina P (2013) Prediction of the time-course pattern of remission in depression by using clinical, neuropsychological, and genetic variables. J Affect Disord 150:1082–1090PubMedCrossRef

Heaton RK, Marcotte TD, Mindt MR, Sadek J, Moore DJ, Bentley H, McCutchan JA, Reicks C, Grant I (2004) The impact of HIV-associated neuropsychological impairment on everyday functioning. J Int Neuropsychol Soc 10:317–331PubMedCrossRef

Judd LL, Paulus MJ, Schettler PJ, Akiskal HS, Endicott J, Leon AC, Maser JD, Mueller T, Solomon DA, Keller MB (2000) Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness? Am J Psychiatry 157:1501–1504PubMedCrossRef

Judd F, Komiti A, Chua P, Mijch A, Hoy J, Grech P, Street A, Lloyd J, Williams B (2005) Nature of depression in patients with HIV/AIDS. Aust N Z J Psychiatry 39:826–832PubMedCrossRef

Keller MB (2004) Remission versus response: the new gold standard of antidepressant care. J Clin Psychiatry 65(Suppl 4):53–59PubMed

Lane TA, Moore DM, Batchelor J, Brew BJ, Cysique LA (2012) Facial emotional processing in HIV infection: relation to neurocognitive and neuropsychiatric status. Neuropsychology 26:713–722PubMedCrossRef

Lee RS, Hermens DF, Porter MA, Redoblado-Hodge MA (2012) A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder. J Affect Disord 140:113–124PubMedCrossRef

Lejuez CW, Hopko DR, Acierno R, Daughters SB, Pagoto SL (2011) Ten year revision of the brief behavioral activation treatment for depression: revised treatment manual. Behav Modif 35:111–161PubMedCrossRef

Mao L, Newman CE, Kidd MR, Saltman DC, Rogers GD, Kippax SC (2009) Self-reported sexual difficulties and their association with depression and other factors among gay men attending high HIV-caseload general practices in Australia. J Sex Med 6:1378–1385PubMedCrossRef

Primeau MM, Avellaneda V, Musselman D, St Jean G, Illa L (2013) Treatment of depression in individuals living with HIV/AIDS. Psychosomatics 54:336–344PubMedCrossRef

Rabkin JG (2008) HIV and depression: 2008 review and update. Curr HIV/AIDS Rep 5:163–171PubMedCrossRef

Relf MV, Eisbach S, Okine KN, Ward T (2013) Evidence-based clinical practice guidelines for managing depression in persons living with HIV. J Assoc Nurses AIDS Care 24:S15–S28PubMedCrossRef

Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33, quiz 34–57 PubMed

Spies G, Asmal L, Seedat S (2013) Cognitive-behavioural interventions for mood and anxiety disorders in HIV: a systematic review. J Affect Disord 150:171–180PubMedCrossRef

Thames AD, Becker BW, Marcotte TD, Hines LJ, Foley JM, Ramezani A, Singer EJ, Castellon SA, Heaton RK, Hinkin CH (2011) Depression, cognition, and self-appraisal of functional abilities in HIV: an examination of subjective appraisal versus objective performance. Clin Neuropsychol 25:224–243PubMedPubMedCentralCrossRef

Title: The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults
Authors: Lucette A. Cysique
Nadene Dermody
Andrew Carr
Bruce J. Brew
Maree Teesson
Publication date: 01-02-2016
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 1/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-015-0368-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2016

Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain

Mind-altering microbes

HSV encephalitis-induced anti-NMDAR encephalitis in a 67-year-old woman: report of a case and review of the literature

Diabolical effects of rabies encephalitis

Peripheral aetiopathogenic drivers and mediators of Parkinson’s disease and co-morbidities: role of gastrointestinal microbiota

Blood brain barrier impairment is associated with cerebrospinal fluid markers of neuronal damage in HIV-positive patients