Published in:
01-12-2017 | Breast
The role of cone-beam breast-CT for breast cancer detection relative to breast density
Published in: European Radiology | Issue 12/2017
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Objectives
To evaluate the impact of breast density on the diagnostic accuracy of non-contrast cone-beam breast computed tomography (CBBCT) in comparison to mammography for the detection of breast masses.
Methods
A retrospective study was conducted from August 2015 to July 2016. Fifty-nine patients (65 breasts, 112 lesions) with BI-RADS, 5th edition 4 or 5 assessment in mammography and/or ultrasound of the breast received an additional non-contrast CBBCT. Independent double blind reading by two radiologists was performed for mammography and CBBCT imaging. Sensitivity, specificity and AUC were compared between the modalities.
Results
Breast lesions were histologically examined in 85 of 112 lesions (76%). The overall sensitivity for CBBCT (reader 1: 91%, reader 2: 88%) was higher than in mammography (both: 68%, p<0.001), and also for the high-density group (p<0.05). The specificity and AUC was higher for mammography in comparison to CBBCT (p<0.05 and p<0.001). The interobserver agreement (ICC) between the readers was 90% (95% CI: 86-93%) for mammography and 87% (95% CI: 82-91%) for CBBCT.
Conclusions
Compared with two-view mammography, non-contrast CBBCT has higher sensitivity, lower specificity, and lower AUC for breast mass detection in both high and low density breasts.
Key Points
• Overall sensitivity for non-contrast CBBCT ranged between 88%-91%.
• Sensitivity was higher for CBBCT than mammography in both density types (p<0.001).
• Specificity was higher for mammography than CBBCT in both density types (p<0.05).
• AUC was larger for mammography than CBBCT in both density types (p<0.001).